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一种中性信封型纳米颗粒，包含 pH 响应和 SS 可切割的类脂质材料作为载体用于质粒 DNA。

A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA.

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

出版信息

Adv Healthc Mater. 2013 Aug;2(8):1120-5. doi: 10.1002/adhm.201200431. Epub 2013 Feb 6.

DOI:10.1002/adhm.201200431
PMID:23386367
Abstract

SS-cleavable proton-activated lipid-like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton-sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol).

摘要

SS 可切割质子激活型类脂质材料（ssPalm）在包封 pDNA 的脂质纳米颗粒中作为关键元件发挥作用。ssPalm 包含双重感应基序，可响应细胞内环境；质子海绵单元（叔胺）可响应酸性环境（内体/溶酶体），而二硫键可在还原环境中被切割（细胞质）。

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