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Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions.低炎症性基于脂质纳米颗粒的mRNA疫苗可诱导针对H5N1流感病毒的保护性免疫，且不良反应减少。
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本文引用的文献

1
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions.低炎症性基于脂质纳米颗粒的mRNA疫苗可诱导针对H5N1流感病毒的保护性免疫，且不良反应减少。
Mol Ther. 2025 Feb 5;33(2):529-547. doi: 10.1016/j.ymthe.2024.12.032. Epub 2024 Dec 17.
2
An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses.一种带生育酚支架的可离子化脂质材料，作为一种 mRNA 疫苗平台，可有效诱导细胞毒性 T 细胞反应。
ACS Nano. 2023 Oct 10;17(19):18758-18774. doi: 10.1021/acsnano.3c02251. Epub 2023 Sep 26.
3
Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency.油酸基纳米系统通过抑制中性粒细胞减轻小鼠急性呼吸窘迫综合征：颗粒大小如何影响治疗效果。
J Nanobiotechnology. 2020 Jan 31;18(1):25. doi: 10.1186/s12951-020-0583-y.
4
Discriminating self from non-self in nucleic acid sensing.在核酸识别中区分自我与非自我。
Nat Rev Immunol. 2016 Sep;16(9):566-80. doi: 10.1038/nri.2016.78. Epub 2016 Jul 25.
5
A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA.一种中性信封型纳米颗粒，包含 pH 响应和 SS 可切割的类脂质材料作为载体用于质粒 DNA。
Adv Healthc Mater. 2013 Aug;2(8):1120-5. doi: 10.1002/adhm.201200431. Epub 2013 Feb 6.

Low-inflammatory lipid nanoparticles facilitate safe mRNA vaccination against influenza virus infection.

作者信息

Xu Yuehua, Zhai Guangxi, Yang Da-Peng, Chen Gang

机构信息

Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, Shandong 266113, China.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

出版信息

Mol Ther. 2025 Feb 5;33(2):430-431. doi: 10.1016/j.ymthe.2025.01.020. Epub 2025 Jan 21.

DOI:10.1016/j.ymthe.2025.01.020
PMID:39842427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11852950/
Abstract
摘要