1. Diagnostic and Translational Research Center, Henry Jackson Foundation, Gaithersburg, MD, USA; ; 2. College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China;
J Cancer. 2013;4(1):84-95. doi: 10.7150/jca.5482. Epub 2013 Jan 5.
It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between tumor cells and infiltrated immune cells is associated with physical destructions of the tumor cells, reduction of the tumor burden, and improved clinical prognosis. An increasing number of studies, however, have suggested that aberrant infiltration of immune cells into tumor or normal tissues may promote tumor progression, invasion, and metastasis. Neither the primary reason for these contradictory observations, nor the mechanism for the reported diverse impact of tumor-infiltrating immune cells has been elucidated, making it difficult to judge the clinical implications of infiltration of immune cells within tumor tissues. This mini-review presents several existing hypotheses and models that favor the promoting impact of tumor-infiltrating immune cells on tumor invasion and metastasis, and also analyzes their strength and weakness.
人们普遍认为，免疫细胞浸润肿瘤组织以及肿瘤细胞与浸润免疫细胞的直接物理接触与肿瘤细胞的物理破坏、肿瘤负担的减轻和临床预后的改善有关。然而，越来越多的研究表明，免疫细胞异常浸润肿瘤或正常组织可能促进肿瘤的进展、侵袭和转移。这些相互矛盾的观察结果的主要原因，以及报道的肿瘤浸润免疫细胞的不同影响的机制尚不清楚，这使得判断肿瘤组织中免疫细胞浸润的临床意义变得困难。这篇迷你综述介绍了几种现有的假说和模型，这些假说和模型支持肿瘤浸润免疫细胞对肿瘤侵袭和转移的促进作用，并对它们的优缺点进行了分析。
