高血糖对四氧嘧啶糖尿病大鼠痛阈的影响。

Effect of hyperglycemia on pain threshold in alloxan-diabetic rats.

作者信息

Lee Jana Herrman, Cox Daniel J, Mook Douglas G, McCarty Richard C

机构信息

Departments of Psychology and Behavioral Medicine and Psychiatry, University of Virginia, Charlottesville, VAU.S.A.

出版信息

Pain. 1990 Jan;40(1):105-107. doi: 10.1016/0304-3959(90)91057-P.

DOI:10.1016/0304-3959(90)91057-P

PMID:2339005

Abstract

Insulin-dependent diabetes mellitus (IDDM) is associated with several complications, including painful diabetic neuropathy. Both animal and human investigations suggest an altered pain response in IDDM. Furthermore, it has been suggested that glucose may be an important mediating factor in these painful symptoms. In the present study, pain threshold was assessed via tail flick latency in alloxan-diabetic and control rats. In addition, tail flick latency was determined under conditions of both hyperglycemia and euglycemia in diabetic rats. Conditions of hyperglycemia resulted in a significant decrease in the tail flick latency of alloxan-diabetic rats. In contrast, tail flick latency was significantly increased in diabetic rats following normalization of blood glucose levels. It is concluded that elevated blood glucose levels contribute to a decrease in pain threshold in alloxan-diabetic rats.

摘要

胰岛素依赖型糖尿病（IDDM）与多种并发症相关，包括疼痛性糖尿病神经病变。动物和人体研究均表明，IDDM患者的疼痛反应有所改变。此外，有研究认为葡萄糖可能是这些疼痛症状的重要介导因素。在本研究中，通过测量四氧嘧啶糖尿病大鼠和对照大鼠的甩尾潜伏期来评估疼痛阈值。此外，还测定了糖尿病大鼠在高血糖和血糖正常条件下的甩尾潜伏期。高血糖状态导致四氧嘧啶糖尿病大鼠的甩尾潜伏期显著缩短。相比之下，血糖水平恢复正常后，糖尿病大鼠的甩尾潜伏期显著延长。由此得出结论，血糖水平升高会导致四氧嘧啶糖尿病大鼠的疼痛阈值降低。