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Experimental conditions for obtaining suppressor and helper effects on the primary in vitro immune response by lymphocytes activated by polyclonal T-cell activators.
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Mechanism of action of suppressor cells. In vivo concanavalin-A-activated suppressor cells do not directly affect B cells.
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Immunological studies in the acquired immunodeficiency syndrome. II. Active suppression or intrinsic defect--investigated by mixing AIDS cells with HLA-DR identical normal cells.
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The regulation of T cell responses by spontaneously active suppressor cells.
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Concanavalin-A-activated lymphocytes suppress immune responses in vitro but are helper cells in vivo.
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Effect of irradiation on human T-cell proliferation: low dose irradiation stimulates mitogen-induced proliferation and function of the suppressor/cytotoxic T-cell subset.
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引用本文的文献
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T cell regulation of polyclonal B cell responsiveness. III. Overt T helper and latent T suppressor activities from distinct subpopulations of unstimulated splenic T cells.
J Exp Med. 1981 Apr 1;153(4):844-56. doi: 10.1084/jem.153.4.844.
3
Bovine con A-induced suppressor cells: generation, macrophage requirements and possible mechanisms of regulatory action.
Immunology. 1981 May;43(1):91-100.
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Characterization of rat spleen-cell populations. I. Cell interactions in the regulation of in vitro response to concanavalin A.
Immunology. 1979 Apr;36(4):619-27.
本文引用的文献
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Biological expressions of lymphocyte activation : I. Effects of phytomitogens on antibody synthesis in vitro.
J Exp Med. 1973 Jan 31;137(2):205-23. doi: 10.1084/jem.137.2.205.
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Immunization of dissociated spleen cell cultures from normal mice.
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
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Antibody-induced changes in expression of an immunoglobulin surface antigen.
Eur J Immunol. 1973 May;3(5):351-9. doi: 10.1002/eji.1830030502.
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Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.
J Exp Med. 1972 Dec 1;136(6):1445-60. doi: 10.1084/jem.136.6.1445.
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Reconstitution of immunocompetence in B cells by addition of concanavalin A or concanavalin A-treated thymus cells.
Clin Exp Immunol. 1973 Feb;13(2):213-23.
6
Cell-mediated immune responses in vitro. I. Suppression of the generation of cytotoxic lymphocytes by concanavalin A and concanavalin A-activated spleen cells.
J Exp Med. 1974 Aug 1;140(2):356-69. doi: 10.1084/jem.140.2.356.
7
"Spontaneous" B cell activation due to loss of normal mouse serum suppressor.
Eur J Immunol. 1972 Dec;2(6):514-7. doi: 10.1002/eji.1830020609.
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Suppressor T cells.
Transplant Rev. 1975;26:39-55. doi: 10.1111/j.1600-065x.1975.tb00174.x.
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Off-signals in lymphocyte activation.
Scand J Immunol. 1976;5(5):583-6. doi: 10.1111/j.1365-3083.1976.tb00313.x.
10
T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.
J Exp Med. 1976 Aug 1;144(2):330-44. doi: 10.1084/jem.144.2.330.
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