Division of Respirology, Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
J Hypertens. 2013 Apr;31(4):663-71. doi: 10.1097/HJH.0b013e32835ed5d0.
To examine if the association with hypertension was different between individuals with and without insomnia symptoms.
This was a population-based, multiyear, cross-sectional study with data from the 2005-2008 United States National Health and Nutrition Examination Surveys (n = 12,643). Insomnia symptoms were considered if at least one of difficulty falling asleep, prolonged nocturnal awakening, or early morning awakening was reported, at least five times per month. Short sleep time (<6 h) was also considered in the insomnia definition. Ever doctor-diagnosed self-reported hypertension, self-reported current antihypertensive use, and objectively measured systolic and diastolic hypertension were examined.
There were generally no associations between insomnia symptoms and hypertension when sleep duration was not considered in the insomnia definition and after controlling for covariates. However, there were significantly increased odds of subjective hypertension measures among individuals with insomnia coupled with short sleep time compared to individuals without insomnia after controlling for covariates [e.g. among individuals with any insomnia: odds ratio (OR), 95% confidence interval (CI) of doctor-diagnosed hypertension 1.49, 1.19-1.88; OR, 95% CI of current antihypertensive medications 1.33, 1.04-1.70]. There were no significant associations though between insomnia symptoms accompanied by short sleep time and objective hypertension measures (e.g. among individuals with any insomnia: OR, 95% CI of measured systolic hypertension 1.32, 0.87-2.02; OR, 95% CI of measured diastolic hypertension 0.96, 0.52-1.75).
Insomnia symptoms coupled with short sleep time may be positively related to hypertension, but the lack of association with objective hypertension measures suggests that there may be no true relationship present.
研究有和无失眠症状的个体之间与高血压的关联是否存在差异。
这是一项基于人群的、多年期的、横断面研究,数据来自 2005-2008 年美国国家健康和营养调查(n=12643)。如果至少有一次入睡困难、夜间频繁醒来或清晨早醒报告,每月至少出现 5 次,则认为存在失眠症状。失眠定义中还考虑了睡眠时间短(<6 小时)。检查了医生诊断的自我报告高血压、自我报告的当前使用降压药以及客观测量的收缩压和舒张压高血压。
当不考虑失眠定义中的睡眠时间且在控制了混杂因素后,失眠症状与高血压之间通常没有关联。然而,与没有失眠的个体相比,失眠且睡眠时间短的个体中,主观高血压测量的可能性显著增加,在控制了混杂因素后[例如,在任何失眠的个体中:医生诊断的高血压的比值比(OR),95%置信区间(CI)为 1.49,1.19-1.88;当前使用降压药的 OR,95%CI 为 1.33,1.04-1.70]。然而,失眠症状伴有睡眠时间短与客观高血压测量之间没有显著关联(例如,在任何失眠的个体中:测量的收缩压高血压的 OR,95%CI 为 1.32,0.87-2.02;测量的舒张压高血压的 OR,95%CI 为 0.96,0.52-1.75)。
失眠症状伴有睡眠时间短可能与高血压呈正相关,但与客观高血压测量缺乏关联表明,可能不存在真正的关系。