Abdou Asmaa G, Maraee Alaa H, Eltahmoudy Mohamed, El-Aziz Reem A
Departments of *Pathology †Dermatology and Andrology, Faculty of Medicine, Menofiya University, Shebein Elkom, Egypt.
Am J Dermatopathol. 2013 Oct;35(7):731-7. doi: 10.1097/DAD.0b013e3182819da6.
Many inflammatory mediators and other biological markers are upregulated in psoriatic lesions; some of these alterations also persist in nonlesional skin. Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans (GLUT-1). The present study aimed at evaluating the pattern of expression of GLUT-1 and Ki-67 in psoriatic skin (involved and uninvolved) and correlating their expression with the clinicopathological parameters in the studied patients. This study was carried out on 30 patients presented with chronic plaque psoriasis and 10 apparently healthy volunteers as a control group. GLUT-1 was not expressed in epidermis of normal skin, whereas it was expressed in 76.6% of uninvolved and 86.7% of involved skin of psoriatic patients, where both the latter differed significantly regarding the intensity (P = 0.001) and localization (P = 0.001) of GLUT-1 expression. The percentage of Ki-67 expression did not differ significantly between involved and uninvolved skin of psoriatic patients, but they were higher than that of normal skin of control group. Nucleolar pattern of Ki-67 expression was significantly associated with male sex (P = 0.05), marked parakeratosis (P = 0.01), and marked angiogenesis (P = 0.05). GLUT-1 expression was associated with degree of acanthosis and percentage of Ki-67 expression. From this study, GLUT-1 is upregulated in psoriatic epidermis and may be involved in facilitation of keratinocyte proliferation in psoriasis. Nucleolar pattern of Ki-67 is an indicator of progressive keratinocyte proliferation in psoriasis.
许多炎症介质和其他生物标志物在银屑病皮损中上调；其中一些改变在非皮损皮肤中也持续存在。葡萄糖是细胞的主要能量来源，葡萄糖转运蛋白1是人类最常见的葡萄糖转运蛋白（GLUT-1）。本研究旨在评估GLUT-1和Ki-67在银屑病皮肤（受累和未受累）中的表达模式，并将它们的表达与所研究患者的临床病理参数相关联。本研究对30例慢性斑块状银屑病患者和10名明显健康的志愿者作为对照组进行。GLUT-1在正常皮肤表皮中不表达，而在银屑病患者未受累皮肤的76.6%和受累皮肤的86.7%中表达，后者在GLUT-1表达的强度（P = 0.001）和定位（P = 0.001）方面均有显著差异。银屑病患者受累和未受累皮肤中Ki-67的表达百分比无显著差异，但均高于对照组的正常皮肤。Ki-67表达的核仁模式与男性性别（P = 0.05）、显著的角化不全（P = 0.01）和显著的血管生成（P = 0.05）显著相关。GLUT-1表达与棘层肥厚程度和Ki-67表达百分比相关。从本研究可知，GLUT-1在银屑病表皮中上调，可能参与促进银屑病中角质形成细胞的增殖。Ki-67的核仁模式是银屑病中角质形成细胞进行性增殖的一个指标。
