Liu C S, Fang S D, Huang M F, Kao Y L, Hsu J S
Sci Sin. 1978 Jul-Aug;21(4):483-502.
Deoxyschisandrin (VIII) and five new lignans, named schisantherin A, B, C, D, and E, were isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils. Their configurations and conformations were established by exhaustive spectral analysis as well as chemical degradations as shown in Ia, Ib; IIa, IIb; IIIa, IIIb; IVa, IVb, and Va, Vb respectively, and their absolute configurations at biphenyl, at C6, C7, and C8 were all assigned to be S form. The position of the methylenedioxyl group in the structures of gamma-schisandrin and Wuweizisu C (as described in the literature), isolated from Schisandra chinensis, must be corrected as shown in VI and VII respectively. In pharmacologica studies and preliminary clinical trials, schisantherin A, B, C, and D showed good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Schisantherin E and deoxyschisandrin were not effective.
从华中五味子果实的活性部位中分离得到了脱氧五味子素（VIII）以及5个新的木脂素，分别命名为五味子酯甲、乙、丙、丁和戊。通过详尽的光谱分析以及化学降解确定了它们的构型和构象，分别如图Ia、Ib；IIa、IIb；IIIa、IIIb；IVa、IVb以及Va、Vb所示，它们在联苯处、C6、C7和C8处的绝对构型均被确定为S型。从五味子中分离得到的γ-五味子素和五味子丙素（如文献所述）结构中的亚甲二氧基的位置必须分别校正为如图VI和VII所示。在药理学研究和初步临床试验中，五味子酯甲、乙、丙和丁在降低慢性病毒性肝炎患者血清谷丙转氨酶水平方面显示出良好效果。五味子酯戊和脱氧五味子素无效。
