Silvestri G, Munoz C, Butini L, Bagnarelli P, Montroni M
Service of Clinical Immunology, Department of Internal Medicine, University of Ancona Medical School, Italy.
Viral Immunol. 1997;10(4):207-12. doi: 10.1089/vim.1997.10.207.
Although CD4+ T cells are the main target of HIV infection, CD8+ cells also play important roles in the interaction between HIV and the host immune system. The aim of this study was to analyze the effect of anti-HIV therapy on the relative proportion of some important CD8+ cell subpopulations. Five HIV-infected patients were enrolled, and blood samples were collected several times, within 90 days from the initiation of therapy. CD4+ cell count and HIV viremia were investigated, as well as the expression of CD38, HLA-DR, CD28, CD57, CD30, CD95 molecules on CD8+ cells. A complex remodeling of CD8+ cell subpopulations took place between week 2 and week 7 of treatment. This remodeling mainly consisted of: i) decrease of CD8+CD38+ and CD8+DR+ cells; ii) increase of CD8+CD28+ cells; and iii) decreased expression of the CD95/Fas molecule on CD8+ cells. Overall, these findings suggest that effective anti-HIV therapy induces changes of CD8+ subpopulations showing the reversal of the state of chronic activation that is caused by viral replication.
虽然CD4+ T细胞是HIV感染的主要靶细胞，但CD8+细胞在HIV与宿主免疫系统的相互作用中也发挥着重要作用。本研究的目的是分析抗HIV治疗对一些重要CD8+细胞亚群相对比例的影响。招募了5名HIV感染患者，并在治疗开始后的90天内多次采集血样。检测了CD4+细胞计数和HIV病毒血症，以及CD8+细胞上CD38、HLA-DR、CD28、CD57、CD30、CD95分子的表达。在治疗的第2周和第7周之间，CD8+细胞亚群发生了复杂的重塑。这种重塑主要包括：i）CD8+CD38+和CD8+DR+细胞减少；ii）CD8+CD28+细胞增加；iii）CD8+细胞上CD95/Fas分子的表达降低。总体而言，这些发现表明有效的抗HIV治疗可诱导CD8+亚群的变化，显示出由病毒复制引起的慢性激活状态的逆转。
