抗组蛋白 H3 作为人食管鳞状细胞癌的独立预后因素。
Anti-phosphohistone H3 as an independent prognostic factor in human esophageal squamous cell carcinoma.
机构信息
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.
出版信息
Anticancer Res. 2013 Feb;33(2):461-7.
BACKGROUND
The immunohistochemical staining of phospho-histone H3 (PHH3) has recently been reported to predict the prognosis of different tumors. However, it has not been evaluated in esophageal squamous cell carcinoma (ESCC). The aim of this study was to evaluate the prognostic impact of PHH3 in ESCC.
MATERIALS AND METHODS
The number of anti-phophohistone H3-positive nuclei [i.e. PHH3 mitotic index (MI)] was calculated by immunohistochemistry of 50 primary tumor samples obtained from patients with ESCC who underwent curative esophagectomy.
RESULTS
The PHH3 MI per 10 high-power fields ranged from 1 to 72 (median=15.5). When the patients were divided into two groups using a cut-off value of 10, the 5-year survival rate of the patients with PHH3 MI ≤10 was significantly higher than that of patients with PHH3 MI >10. Multivariate analysis indicated PHH3 MI to be an independent prognostic factor.
CONCLUSION
The expression of PHH3 impacts the prognosis of patients with ESCC.
背景
磷酸化组蛋白 H3（PHH3）的免疫组织化学染色最近被报道可预测不同肿瘤的预后。然而，它尚未在食管鳞状细胞癌（ESCC）中进行评估。本研究旨在评估 PHH3 在 ESCC 中的预后影响。
材料和方法
通过对 50 例接受根治性食管切除术的 ESCC 患者的原发性肿瘤样本进行免疫组织化学分析，计算抗磷酸化组蛋白 H3 阳性核的数量[即 PHH3 有丝分裂指数（MI）]。
结果
每 10 个高倍视野的 PHH3 MI 范围为 1 至 72（中位数=15.5）。当使用 10 的截断值将患者分为两组时，PHH3 MI ≤10 的患者的 5 年生存率明显高于 PHH3 MI >10 的患者。多变量分析表明 PHH3 MI 是独立的预后因素。
结论
PHH3 的表达影响 ESCC 患者的预后。
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