Department of Pediatric Nephrology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
Ren Fail. 2013;35(3):327-32. doi: 10.3109/0886022X.2013.764254. Epub 2013 Feb 11.
Identifying the risk factors is important in prevention of urinary tract infections (UTIs) in children. The aim of this study is to evaluate the association of UTI and idiopathic hypercalciuria (IHC).
Two hundred and twenty-four children aged between 1 month and 16 years and diagnosed to have UTI were evaluated for urinary calcium excretion. The children were diagnosed to have IHC if their urinary calcium/creatinine ratios in at least two different spot urine samples were >0.6 between 0-1 year old and ≥0.21 over 1 year or daily calcium excretion >4 mg/kg.
The frequency of IHC was found to be 16.7%. Family history of urolithiasis, parental consanguinity, presentation with abdominal pain, loss of appetite, and discomfort were found to be significantly higher in the IHC group. No association was found between IHC and the recurrence of UTI, presence of vesicoureteral reflux, renal scar formation, and the prognosis.
IHC should be considered among the risk factors for UTI and should be investigated particularly in patients with family history of urinary stones and suggestive complaints of IHC.
识别风险因素对于预防儿童尿路感染（UTI）很重要。本研究旨在评估 UTI 与特发性高钙尿症（IHC）之间的关联。
评估了 224 名年龄在 1 个月至 16 岁之间被诊断患有 UTI 的儿童的尿钙排泄情况。如果儿童在至少两次不同的随机尿液样本中的尿钙/肌酐比值在 0-1 岁时大于 0.6，或在 1 岁以上时大于 0.21，或每日钙排泄量大于 4mg/kg，则诊断为 IHC。
发现 IHC 的发生率为 16.7%。IHC 组的家族性尿路结石史、父母近亲结婚、腹痛、食欲不振和不适等症状的发生率明显较高。但未发现 IHC 与 UTI 复发、存在膀胱输尿管反流、肾瘢痕形成和预后之间存在关联。
应将 IHC 视为 UTI 的危险因素之一，特别是对于有尿路结石家族史和 IHC 提示症状的患者，应进行相关检查。
