King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Am J Ophthalmol. 2013 May;155(5):882-9. doi: 10.1016/j.ajo.2012.12.006. Epub 2013 Feb 6.
To compare the demographic and clinical distribution of primary and secondary congenital glaucoma from a registry at King Khaled Eye Specialist Hospital.
Registry-based cohort study.
Review of registry data that included new patients with congenital glaucoma seen between 2001 and 2003 (29 months); analysis of the demographic data and clinical features of primary and secondary congenital glaucoma at presentation.
A total of 325 eyes of 180 patients were included. Most patients had primary congenital glaucoma (80%). The mean (± SD) age at presentation for primary congenital glaucoma was 3.8 ± 10.7 months and for secondary congenital glaucoma was 4.3 ± 7.9 months. Most primary congenital glaucoma and secondary congenital glaucoma patients had bilateral disease (82.6%; 74.3%). Primary congenital glaucoma was equally distributed by sex but secondary congenital glaucoma was 1.5-fold more common in male patients. A positive family history was elicited in 30%, and almost 60% had a history of consanguinity in both groups. The mean intraocular pressure and corneal diameter were comparable in both groups but the axial length was significantly longer in primary congenital glaucoma and cup-to-disc (C/D) ratio greater in secondary congenital glaucoma. In the primary congenital glaucoma group, corneal haze showed a significant relationship with most clinical parameters. In primary congenital glaucoma, a positive correlation was noted between age at presentation and increasing corneal diameter and axial length but a negative relationship was noted with C/D ratio and corneal haze, whereas for secondary congenital glaucoma only axial length was positively correlated.
The congenital glaucoma registry provides unique baseline data on primary congenital glaucoma and secondary congenital glaucoma in Saudi Arabia that will enable us to better understand the disease in the Kingdom and region.
比较 King Khaled 眼科专科医院青光眼登记处原发性和继发性先天性青光眼的人口统计学和临床分布。
基于登记的队列研究。
回顾性分析 2001 年至 2003 年（29 个月）间新诊断的先天性青光眼患者的登记数据；分析原发性和继发性先天性青光眼患者的人口统计学数据和临床特征。
共纳入 180 例患者的 325 只眼。大多数患者为原发性先天性青光眼（80%）。原发性先天性青光眼患者的平均（±标准差）就诊年龄为 3.8±10.7 个月，继发性先天性青光眼为 4.3±7.9 个月。大多数原发性先天性青光眼和继发性先天性青光眼患者均为双侧疾病（82.6%；74.3%）。原发性先天性青光眼患者性别分布均衡，但继发性先天性青光眼男性患者是女性患者的 1.5 倍。两组均有 30%的患者有阳性家族史，近 60%的患者均有近亲婚配史。两组的平均眼压和角膜直径相似，但原发性先天性青光眼的眼轴长度明显较长，继发性先天性青光眼的杯盘比（C/D 比值）较大。在原发性先天性青光眼组中，角膜混浊与大多数临床参数呈显著相关。在原发性先天性青光眼患者中，就诊年龄与角膜直径和眼轴长度呈正相关，与 C/D 比值和角膜混浊呈负相关，而继发性先天性青光眼患者中仅眼轴长度与 C/D 比值呈正相关。
青光眼登记处提供了沙特阿拉伯原发性和继发性先天性青光眼的独特基线数据，使我们能够更好地了解该疾病在王国和该地区的情况。
