IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I.R.S.T. S.r.l., Meldola, 47014 FC, Italy.
Clin Biochem. 2013 Jul;46(10-11):918-25. doi: 10.1016/j.clinbiochem.2013.01.024. Epub 2013 Feb 8.
Lung cancer is the leading cause of cancer deaths worldwide and few genetic markers enable to evaluate lung cancer risk. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression during various cell processes such as apoptosis, differentiation and development. In these last years, many works confirm a role for miRNAs in the initiation and progression of lung cancer. miRNA profiling has the potential to classify tumors with high accuracy and predict outcome. Here, we describe the roles of miRNA in lung carcinogenesis and the possibility to use them as biological markers for diagnostic, prognostic and predictive purposes.
肺癌是全球癌症死亡的主要原因，很少有遗传标志物能够评估肺癌风险。microRNAs（miRNAs）是一类在细胞凋亡、分化和发育等各种细胞过程中调节基因表达的小非编码 RNA。在过去的几年中，许多研究证实了 miRNAs 在肺癌的发生和发展中的作用。miRNA 谱分析有可能以高精度对肿瘤进行分类，并预测其结果。在这里，我们描述了 miRNA 在肺癌发生中的作用，以及将其用作诊断、预后和预测目的的生物标志物的可能性。
