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基于 DMBA 小鼠模型和 miRNA、mTOR 基因表达生物标志物的多酚和咖啡的化学预防作用。

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers.

机构信息

Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary.

Department of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.

出版信息

Cells. 2022 Apr 12;11(8):1300. doi: 10.3390/cells11081300.

DOI:10.3390/cells11081300
PMID:35455979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9029301/
Abstract

Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea () extract, polyphenol extract (a mixture of blackberry (), blackcurrants (), and added resveratrol phytoalexin), Chinese bayberry () extract, and a coffee () extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in the liver of the Chinese bayberry extract-consuming group, and miR-132 in the kidneys of the polyphenol-fed group. In the coffee extract-consuming group, only miR-9-3 and mTOR decreased significantly in the liver; also, miR-134 decreased significantly in the spleen, and, additionally, miR-124-1 decreased significantly in the kidney. Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-κB; as well as oncogenes, namely and . The examined chemopreventive agents, besides the obvious antioxidant and anti-inflammatory effects, mainly blocked the mentioned DMBA-activated factors and the mitogen-activated protein kinase (MAPK) as well, and, at the same time, induced as well as tumor suppressor genes.

摘要

多酚具有降低癌症风险的能力。我们研究了绿茶（）提取物、多酚提取物（黑莓（）、黑加仑（）和添加的白藜芦醇植物抗毒素的混合物）、杨梅（）提取物和咖啡（）提取物对 7,12-二甲基苯并[a]蒽（DMBA）致癌物诱导的 CBA/Ca 小鼠肝脏、脾脏和肾脏中 miR-134、miR-132、miR-124-1、miR-9-3 和 基因表达的化学预防作用。除了杨梅提取物组的肝脏中的 miR-132 和多酚组的肾脏中的 miR-132 外，在这些器官中，升高现象显著减弱。在咖啡提取物组中，只有 miR-9-3 和 mTOR 在肝脏中显著降低；此外，miR-134 在脾脏中显著降低，miR-124-1 在肾脏中显著降低。我们的结果得到了文献数据的支持，特别是 DMBA 生成的 ROS 诱导的炎症和增殖信号转导物，如 TNF、IL1、IL6 和 NF-κB；以及癌基因，即 和 。除了明显的抗氧化和抗炎作用外，所研究的化学预防剂主要阻断了上述 DMBA 激活的因子和有丝分裂原激活蛋白激酶（MAPK），同时诱导 以及肿瘤抑制基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/837fef1a3a78/cells-11-01300-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/84b6c903fc1e/cells-11-01300-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/b6c8f80097d8/cells-11-01300-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/7a957d4ccfca/cells-11-01300-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/395e7bb307ee/cells-11-01300-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/837fef1a3a78/cells-11-01300-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/84b6c903fc1e/cells-11-01300-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/b6c8f80097d8/cells-11-01300-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/7a957d4ccfca/cells-11-01300-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/395e7bb307ee/cells-11-01300-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e4/9029301/837fef1a3a78/cells-11-01300-g005.jpg

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