LRF/Pokemon 在谱系命运决定中的作用。
Role of LRF/Pokemon in lineage fate decisions.
机构信息
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
出版信息
Blood. 2013 Apr 11;121(15):2845-53. doi: 10.1182/blood-2012-11-292037. Epub 2013 Feb 8.
Abstract
In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.
摘要
在人类基因组中，发现了 43 个不同的基因，它们编码属于 POK（痘病毒和锌指和 Krüppel）/ZBTB（锌指和广泛复合物、tramtrack、bric-à-brac）因子家族的蛋白质。这些基因通常被认为是转录抑制剂，其中一些在各种组织的细胞谱系命运决定中起着重要作用，为生物体的整个生命周期编程特定的任务。在这里，我们重点关注白血病/淋巴瘤相关因子/POK 红细胞髓样发生因子的功能，它可能是 POK/ZBTB 家族中最令人兴奋和神秘的成员之一。
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