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马来酰亚胺功能化的铂(IV)配合物作为靶向药物传递的合成平台。

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

机构信息

University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A-1090, Vienna, Austria.

Research Platform "Translational Cancer Therapy Research" University of Vienna, Waehringer Strasse 42, A-1090, Vienna, Austria.

出版信息

Chem Commun (Camb). 2013 Mar 18;49(22):2249-2251. doi: 10.1039/c3cc39258a.

DOI:10.1039/c3cc39258a
PMID:23396381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4021452/
Abstract

Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.

摘要

合成了具有巯基高选择性结合性能的马来酰亚胺功能化的 Pt(IV) 配合物，作为结合含巯基的肿瘤靶向分子（如人血清白蛋白）的前体。

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本文引用的文献

1
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J Inorg Biochem. 2012 Dec;117:220-9. doi: 10.1016/j.jinorgbio.2012.06.013. Epub 2012 Jul 2.
2
Anticancer activity of methyl-substituted oxaliplatin analogs.甲氧基取代奥沙利铂类似物的抗癌活性。
Mol Pharmacol. 2012 May;81(5):719-28. doi: 10.1124/mol.111.077321. Epub 2012 Feb 13.
3
Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity.单羧基二胺二氯合铂（IV）配合物的选择性合成、表征和细胞毒性。
Dalton Trans. 2011 Aug 28;40(32):8187-92. doi: 10.1039/c1dt10301f. Epub 2011 Jul 11.
4
Albumin binding ligands and albumin conjugate uptake by cancer cells.白蛋白结合配体和白蛋白缀合物被癌细胞摄取。
Diabetol Metab Syndr. 2011 Jun 15;3(1):11. doi: 10.1186/1758-5996-3-11.
5
Redox metabolism and malignancy.氧化还原代谢与恶性肿瘤。
Curr Opin Pharmacol. 2010 Aug;10(4):362-8. doi: 10.1016/j.coph.2010.05.003. Epub 2010 Jun 4.
6
The status of platinum anticancer drugs in the clinic and in clinical trials.铂类抗癌药物在临床和临床试验中的地位。
Dalton Trans. 2010 Sep 21;39(35):8113-27. doi: 10.1039/c0dt00292e. Epub 2010 Jun 30.
7
Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.多价寡核苷酸金纳米粒子缀合物作为铂(IV)弹头的递送载体。
J Am Chem Soc. 2009 Oct 21;131(41):14652-3. doi: 10.1021/ja9071282.
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Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer.白蛋白结合型紫杉醇（Abraxane ABI-007）治疗乳腺癌
Int J Nanomedicine. 2009;4:99-105. doi: 10.2147/ijn.s3061. Epub 2009 Apr 20.
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Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.使用叶酸作为归巢装置的靶向单壁碳纳米管介导的铂（IV）前药递送。
J Am Chem Soc. 2008 Aug 27;130(34):11467-76. doi: 10.1021/ja803036e. Epub 2008 Jul 29.
10
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.白蛋白作为药物载体：前药、药物偶联物及纳米颗粒的设计
J Control Release. 2008 Dec 18;132(3):171-83. doi: 10.1016/j.jconrel.2008.05.010. Epub 2008 May 17.