马来酰亚胺功能化的铂(IV)配合物作为靶向药物传递的合成平台。
Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.
机构信息
University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A-1090, Vienna, Austria.
Research Platform "Translational Cancer Therapy Research" University of Vienna, Waehringer Strasse 42, A-1090, Vienna, Austria.
出版信息
Chem Commun (Camb). 2013 Mar 18;49(22):2249-2251. doi: 10.1039/c3cc39258a.
Abstract
Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.
摘要
合成了具有巯基高选择性结合性能的马来酰亚胺功能化的 Pt(IV) 配合物，作为结合含巯基的肿瘤靶向分子（如人血清白蛋白）的前体。
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