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接受非甾体抗炎药或泼尼松长期口服治疗的C57BL小鼠膝关节自发性骨关节炎

Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone.

作者信息

Pataki A, Graf H P, Witzemann E

机构信息

Pharmaceuticals Division, Ciba-Geigy Limited, Basle, Switzerland.

出版信息

Agents Actions. 1990 Mar;29(3-4):210-7. doi: 10.1007/BF01966449.

DOI:10.1007/BF01966449
PMID:2339667
Abstract

In a statistically planned study based on quantitative radiography, treatment for 25-26 weeks with the 2 NSAIDs, diclofenac sodium, or indomethacin (both 0.5 and 1.5 mg/kg p.o. daily), or prednisone (6 mg/kg p.o.) had no influence on the progression of spontaneous osteo-arthritis of the knee-joint of the C57BL mouse, by comparison with placebo-treated controls.

摘要

在一项基于定量放射学的统计学规划研究中，与接受安慰剂治疗的对照组相比，用两种非甾体抗炎药（双氯芬酸钠或吲哚美辛，均为每日口服0.5毫克/千克和1.5毫克/千克）或泼尼松（每日口服6毫克/千克）对C57BL小鼠膝关节自发性骨关节炎的进展进行25 - 26周的治疗，没有产生影响。

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引用本文的文献

1
Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse.C57BL小鼠膝关节骨关节炎的定量放射学诊断
Agents Actions. 1990 Mar;29(3-4):201-9. doi: 10.1007/BF01966448.

本文引用的文献

1
Degenerative joint disease of mice as modified by adrenocorticotrophic hormone (ACTH).促肾上腺皮质激素（ACTH）对小鼠退行性关节病的影响。
Exp Med Surg. 1955;13(3):279-85.
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Degenerative joint disease in mice bearing anterior hypophyseal, ovarian and adrenal grafts.
Endocrinology. 1954 Jan;54(1):26-34. doi: 10.1210/endo-54-1-26.
3
A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically.兔骨关节炎新模型。II. 全身给药的选定抗风湿药物的抗骨关节炎作用评估。
Arthritis Rheum. 1983 Sep;26(9):1132-9. doi: 10.1002/art.1780260911.
4
A new model of osteoarthritis in rabbits. III. Evaluation of anti-osteoarthritic effects of selected drugs administered intraarticularly.兔骨关节炎新模型。III. 关节内注射特定药物的抗骨关节炎作用评估
Arthritis Rheum. 1983 Nov;26(11):1380-6. doi: 10.1002/art.1780261111.
5
Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage.己曲安奈德可预防化学诱导的关节软骨损伤后的纤维化和骨赘形成。
Arthritis Rheum. 1985 Nov;28(11):1267-74. doi: 10.1002/art.1780281111.
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Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis. Suppression by steroids.实验性骨关节炎中中性蛋白聚糖酶引起的软骨降解。类固醇的抑制作用。
Arthritis Rheum. 1985 Dec;28(12):1393-401. doi: 10.1002/art.1780281212.
7
Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse.C57BL小鼠膝关节骨关节炎的定性影像学诊断
Agents Actions. 1987 Oct;22(1-2):123-30. doi: 10.1007/BF01968827.
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Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse.C57BL小鼠膝关节骨关节炎的定量放射学诊断
Agents Actions. 1990 Mar;29(3-4):201-9. doi: 10.1007/BF01966448.
9
[Preventive effect of tribenoside in spontaneous arthrosis of the mouse].曲克芦丁对小鼠自发性关节病的预防作用
Z Rheumatol. 1977 Mar-Apr;36(3-4):112-9.
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[Animal experiment studies on the effect of intra-articular injections of antiphlogistic-antirheumatic agents on articular cartilage in vivo].
Z Rheumatol. 1978 Nov-Dec;37(11-12):380-94.