Pataki A, Reife R, Witzemann E, Graf H P, Schweizer A
Pharmaceuticals Division, Ciba-Geigy Limited, Basle, Switzerland.
Agents Actions. 1990 Mar;29(3-4):201-9. doi: 10.1007/BF01966448.
Comparative histopathological and radiographic investigations in the C57BL mouse model of spontaneous osteo-arthritis of the knee-joint indicate that there is a relation between quantitative radiographic diagnosis and semiquantitative histopathological diagnosis. Statistical analysis based on a set of quantitative radiographic parameters of the mouse knee-joint shows that the greater part of the radiographic information reflecting the histopathological degree of the osteo-arthritis is contained in the projection areas of the lateral and medial meniscus: progression of the osteo-arthritic process is accompanied with enlargement of the menisci. On the basis of these observations, a radiography score for the osteo-arthritis has been constructed, which consists of a weighted sum of the - suitably transformed - projection areas of the lateral and medial meniscus. In addition to the size of the menisci, the width of the joint space is also a useful quantitative parameter of osteo-arthritis of the mouse knee-joint.
对C57BL小鼠膝关节自发性骨关节炎模型进行的比较组织病理学和影像学研究表明，定量影像学诊断与半定量组织病理学诊断之间存在关联。基于一组小鼠膝关节定量影像学参数的统计分析表明，反映骨关节炎组织病理学程度的大部分影像学信息包含在外侧和内侧半月板的投影区域中：骨关节炎进程的进展伴随着半月板的增大。基于这些观察结果，构建了一种骨关节炎的影像学评分，该评分由外侧和内侧半月板（经过适当转换后的）投影区域的加权和组成。除了半月板的大小外，关节间隙的宽度也是小鼠膝关节骨关节炎的一个有用的定量参数。
