Pataki A, Fries R, Ochsner K, Witzemann E
Pharmaceutical Research Laboratories, CIBA-GEIGY Limited, Basle, Switzerland.
Agents Actions. 1987 Oct;22(1-2):123-30. doi: 10.1007/BF01968827.
Experiments were performed to assess the diagnostic value of radiography in osteo-arthritis (OA) of the knee joint in C57Bl mice. Comparative histological and radiographic examination of knee joints from 96 animals showed that if the classical diagnostic criteria (narrowing of the joint space, sclerosis of the subchondral bone, deformation of the joint epiphyses) are applied, OA is not readily detectable by radiography. If these criteria are extended to include radiographic changes in the menisci (enlargement, deformation, increased and/or heterogeneous density), the frequency of detection is much improved. However, except in the severest forms of OA, radiography does not afford a satisfactory means of distinguishing between various degrees of severity. The qualitatively evaluated data nevertheless do suggest that quantitative radiographic diagnosis of OA of the murine knee joint may be useful, both for improving the detection rate and for discriminating various degrees of OA.
进行实验以评估X线摄影在C57Bl小鼠膝关节骨关节炎（OA）中的诊断价值。对96只动物的膝关节进行组织学和X线摄影对比检查发现，如果采用经典诊断标准（关节间隙变窄、软骨下骨硬化、关节骨骺变形），X线摄影不易检测出OA。如果将这些标准扩展至包括半月板的X线摄影变化（增大、变形、密度增加和/或不均匀），检测频率会大大提高。然而，除了最严重的OA形式外，X线摄影无法提供区分不同严重程度的令人满意的方法。不过，定性评估的数据确实表明，小鼠膝关节OA的定量X线摄影诊断可能有助于提高检测率和区分不同程度的OA。
