Department of Pediatric Hematology-Oncology, IRCCS, Ospedale Bambino Gesù, Rome, Italy.
Ann Hepatol. 2013 Mar-Apr;12(2):308-14.
Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer.
Eight children who developed FNH and HRN after treatment for malignancies in the Oncology unit at the "Bambino Gesù" Pediatric Hospital in Rome, were retrospectively analyzed.
The lesions, considered in the differential diagnosis with metastatic relapse of the primitive disease, have been monitored with US or other available imaging techniques. Evolution of the lesions was observed in only 1 patient three years after the initial diagnosis of FNH.
In conclusion serial monitoring with imaging techniques is sufficient to rule out liver metastasis and to monitor the evolution of the lesions. Surgery is suggested only in the case of complications.
肝再生结节（HRN）和局灶性结节性增生（FNH）是肝脏良性再生病变，在儿童中很少见。在接受癌症治疗的儿童中，这些病变的发病率有所增加。
回顾性分析了在罗马“Bambino Gesù”儿科医院肿瘤科治疗恶性肿瘤后发生 FNH 和 HRN 的 8 名儿童。
这些病变被认为是与原始疾病转移复发的鉴别诊断，仅在 1 例患者中在初始 FNH 诊断后 3 年进行了超声或其他可用的影像学检查。
总之，通过影像学技术进行连续监测足以排除肝转移并监测病变的演变。仅在出现并发症的情况下才建议手术。
