Sady M A, Haydon B B, Sady S P, Carpenter M W, Thompson P D, Coustan D R
Miriam Hospital, Research 225, Providence, RI 02906.
Am J Obstet Gynecol. 1990 May;162(5):1181-5. doi: 10.1016/0002-9378(90)90012-v.
We examined the cardiovascular response at rest and during upright cycle exercise in nine women during pregnancy (25.6 +/- 3.0 weeks' gestation) and at 2 months (8.8 +/- 1.8 weeks) and 7 months (30.0 +/- 2.5 weeks) post partum. Antepartum resting cardiac output, heart rate, and stroke volume were higher, whereas the arterial-venous oxygen difference was lower than both postpartum values. The antepartum resting oxygen uptake did not differ from 2 months post partum but was higher than at 7 months post partum. Cardiac output during submaximal exercise was greater antepartum than at both postpartum tests. Submaximal antepartum oxygen uptake, heart rate, and stroke volume were generally higher, and the arterial-venous oxygen difference was lower than at 7 months post partum. The slope of the antepartum cardiac output versus oxygen uptake relationship did not differ from the value at 2 months post partum, (6.16 +/- 1.38 and 5.84 +/- 1.34, p greater than 0.05) but was higher than at 7 months post partum (5.22 +/- 0.78, p less than 0.05). There were no significant differences in maximal oxygen uptake or heart rate among the three testing periods. Maximal cardiac output and stroke volume were higher antepartum than at 2 and 7 months post partum, whereas the arterial-venous oxygen difference was lower than at 7 months post partum. There were few significant differences in resting, submaximal, or maximal measurements between the two postpartum conditions. These data suggest that the augmented cardiac response to exercise during pregnancy is reduced by 2 months post partum but that additional time may be required for a complete resolution of the cardiovascular changes induced by pregnancy.
我们研究了9名孕期女性（妊娠25.6±3.0周）以及产后2个月（8.8±1.8周）和7个月（30.0±2.5周）时静息状态及直立位骑行运动期间的心血管反应。产前静息心输出量、心率和每搏输出量较高，而动静脉氧差低于产后的两个值。产前静息摄氧量与产后2个月时无差异，但高于产后7个月时。次最大运动期间的心输出量产前高于产后的两次测试。产前次最大摄氧量、心率和每搏输出量通常较高，而动静脉氧差低于产后7个月时。产前心输出量与摄氧量关系的斜率与产后2个月时的值无差异（分别为6.16±1.38和5.84±1.34，p>0.05），但高于产后7个月时（5.22±0.78，p<0.05）。三个测试期之间的最大摄氧量或心率无显著差异。最大心输出量和每搏输出量产前高于产后2个月和7个月时，而动静脉氧差低于产后7个月时。两种产后状态下静息、次最大或最大测量值之间几乎没有显著差异。这些数据表明，孕期运动时增强的心脏反应在产后2个月时有所降低，但可能还需要更多时间才能使妊娠引起的心血管变化完全恢复。
