Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
J Am Chem Soc. 2013 Feb 20;135(7):2470-3. doi: 10.1021/ja3125405. Epub 2013 Feb 11.
An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.
现提出一种操作简单的选择性脱氧氟化复杂结构醇的方法。已制备了几种天然产物和药物的氟化衍生物，以展示该方法在后期多样化和官能团兼容性方面的潜力。还给出了一系列用于预测具有多个醇的底物选择性的简单指导原则。
