Wouters P, Doursout M F, Merin R G, Chelly J E
Department of Anesthesiology, Baylor College of Medicine, University of Texas Medical School, Houston 77030.
Anesthesiology. 1990 May;72(5):843-5. doi: 10.1097/00000542-199005000-00013.
This study was designed to assess the relationship between MAC and hypertension. To this purpose, MAC of halothane was determined in fully inbred spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Because MAC determination was performed in animals whose lungs were mechanically ventilated, the adequacy of the ventilation was initially established in 20 rats equally divided into SHR and WKY, and instrumented with catheters in the abdominal aorta. Subsequently, MAC of halothane was determined in 40 rats equally divided into SHR and WKY, including those instrumented. There were no differences in MAC of halothane between SHR (n = 20) and WKY (n = 20) (1.08 +/- 0.02% vs. 1.11 +/- 0.02%). Subgroup analysis indicated that MAC of halothane was not affected by the presence of an arterial catheter in the abdominal aorta (SHR 1.09 +/- 0.06% vs. 1.08 +/- 0.02%; WKY 1.15 +/- 0.04% vs. 1.08 +/- 0.02%). The authors' data provide experimental evidence that MAC is not affected by either chronic hypertension or limited instrumentation.
本研究旨在评估最低肺泡有效浓度（MAC）与高血压之间的关系。为此，在纯系自发性高血压大鼠（SHR）和Wistar Kyoto大鼠（WKY）中测定了氟烷的MAC。由于MAC测定是在机械通气的动物中进行的，因此最初在20只大鼠中确定通气是否充分，这些大鼠平均分为SHR组和WKY组，并在腹主动脉中插入导管。随后，在40只大鼠中测定氟烷的MAC，这些大鼠平均分为SHR组和WKY组，包括已插入导管的大鼠。SHR组（n = 20）和WKY组（n = 20）的氟烷MAC无差异（1.08±0.02%对1.11±0.02%）。亚组分析表明，腹主动脉中存在动脉导管不影响氟烷的MAC（SHR组1.09±0.06%对1.08±0.02%；WKY组1.15±0.04%对1.08±0.02%）。作者的数据提供了实验证据，表明MAC不受慢性高血压或有限器械植入的影响。
