Department of Environmental Science, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
J Microencapsul. 2013;30(5):498-509. doi: 10.3109/02652048.2012.758179. Epub 2013 Feb 12.
Chitosan-encapsulated menthol microcapsules were successfully prepared in an oil-in-water (o/w) emulsion using the Shirasu Porous Glass (SPG) membrane emulsification technique and high-speed dispersion technique for preparing a mixed o/w emulsion. The size of the menthol-loaded chitosan microcapsules was strongly depended on the average pore size of the SPG membrane and the amount of menthol loading in the dispersed phase. The membrane pore size of 5.2 µm was suitable for a viscous dispersed phase containing light mineral oil. The average diameter of emulsion droplets of 28.3 µm was obtained. Increasing the menthol loading in the dispersion phase from 5% to 10% w/w of chitosan decreased the emulsion droplet size with a broad size distribution. The crosslinked microcapsule size and size distribution of mixed emulsion droplets decreased with the increasing crosslinking time. The menthol release was a diffusion control which depended on the proportion of amino group in chitosan-to-tripolyphosphate molar ratio and crosslinking time. This work also demonstrated that hydrophilicity/hydrophobicity of the continuous phase and dispersion phase controlled SPG membrane emulsification efficiency and quality of the resulting emulsion droplets.
壳聚糖包封薄荷醇微胶囊成功地使用玻璃纤维膜乳化技术在油包水（o/w）乳液中制备，使用高速分散技术制备混合 o/w 乳液。载有薄荷醇的壳聚糖微胶囊的尺寸强烈依赖于 Shirasu Porous Glass（SPG）膜的平均孔径和分散相中的薄荷醇负载量。膜孔径为 5.2μm 适用于含有轻质矿物油的粘性分散相。获得了 28.3μm 的乳液液滴的平均直径。增加分散相中的薄荷醇负载量，从壳聚糖的 5%w/w 增加到 10%w/w，降低了乳液液滴的尺寸，同时具有较宽的尺寸分布。交联微胶囊的尺寸和混合乳液液滴的尺寸分布随着交联时间的增加而减小。薄荷醇的释放是扩散控制，这取决于壳聚糖与三聚磷酸酯摩尔比中的氨基比例和交联时间。这项工作还表明，连续相和分散相的亲水性/疏水性控制了 SPG 膜乳化效率和所得乳液液滴的质量。
