Department of Gastroenterology, Medical School, LIM 35, University of São Paulo, São Paulo, Brazil.
Clin Nutr. 2013 Aug;32(4):503-10. doi: 10.1016/j.clnu.2012.12.008. Epub 2012 Dec 22.
Fish oil-based lipid emulsions (FOLEs) have shown post-operative immunological and clinical benefits in parenteral nutrition.
To assess post-operative immune response after short-term pre-operative parenteral infusion of isolated FOLE in gastrointestinal cancer patients.
The patients (n = 63) received pre-operative peripheral infusion (0.2 g fat/kg body weight/d) of FOLE (Omegaven(®)) or control lipid emulsion (MCT/LCT; Lipovenos MCT(®)) for 3 days. Post-operative concentrations of inflammatory mediators, leukocyte functions, surface molecules, infections, and length of intensive care unit (ICU) and hospital stay were measured.
FOLE patients had a significant increase of IL-10 levels on day 3, decrease of IL-6 and IL-10 levels on day 6, lower decrease in leukocyte oxidative burst, maintenance of monocyte percentage expressing HLA-DR and CD32, and increase of CD32 neutrophil expression compared to MCT/LCT patients. No changes were observed in the frequency of post-operative infections or length of ICU and hospital stay.
Short-term pre-operative infusion of FO alone improves the post-operative immune response of gastrointestinal cancer patients without significantly changing post-operative infections or length of ICU and hospital stay. ID:NCT01218841.
鱼油为基础的脂肪乳剂（FOLE）在肠外营养中显示出术后免疫和临床益处。
评估胃肠道癌症患者短期术前肠外输注分离 FOLE 后的术后免疫反应。
患者（n=63）接受 FOLE（Omegaven®）或对照脂肪乳剂（MCT/LCT；Lipovenos MCT®）术前外周输注（0.2 g 脂肪/公斤体重/天）3 天。测量术后炎症介质、白细胞功能、表面分子、感染以及重症监护病房（ICU）和住院时间。
FOLE 组患者在第 3 天 IL-10 水平显著升高，第 6 天 IL-6 和 IL-10 水平下降，白细胞氧化爆发下降幅度较小，单核细胞表达 HLA-DR 和 CD32 的比例保持不变，CD32 中性粒细胞表达增加，与 MCT/LCT 组相比。术后感染的频率或 ICU 和住院时间均无变化。
单独短期术前输注 FO 可改善胃肠道癌症患者的术后免疫反应，而不会显著改变术后感染或 ICU 和住院时间。标识符：NCT01218841。
