载银纳米粒子的羧甲基壳聚糖/聚氧化乙烯纳米纤维的抗菌活性。
Antimicrobial activity of carboxymethyl chitosan/polyethylene oxide nanofibers embedded silver nanoparticles.
机构信息
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
出版信息
Carbohydr Polym. 2013 Feb 15;92(2):1012-7. doi: 10.1016/j.carbpol.2012.10.047. Epub 2012 Oct 26.
A facile method to synthesize silver nanoparticles (AgNPs) using carboxymethyl chitosan (CMCTS), which act as reducing agent for silver ions as well as protecting agent for the formed AgNPs, is reported. CMCTS embedded AgNPs are mixed with polyethylene oxide (PEO). The blend polymers containing AgNPs are electrospun resulting in blend nano-fiber mats. The formation of AgNPs has been confirmed using UV-vis and TEM. The diameter range of 12-18 nm of well-dispersed AgNPs with a concentration of 100 ppm was obtained. The electrospun mats are characterized using SEM, EDX as well as TGA. Antimicrobial activity against different species of pathogenic/nonpathogenic; Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 in addition to the fungus Candida albicans ATCC 10231 was studied. The results show excellent antimicrobial activity compared with nanofibers without AgNPs and AgNPs alone.
本文报道了一种使用羧甲基壳聚糖（CMCTS）合成银纳米粒子（AgNPs）的简便方法。CMCTS 不仅可以作为银离子的还原剂，还可以作为形成的 AgNPs 的保护剂。将嵌入 CMCTS 的 AgNPs 与聚氧化乙烯（PEO）混合。将含有 AgNPs 的共混聚合物进行静电纺丝，得到共混纳米纤维毡。通过 UV-vis 和 TEM 确认了 AgNPs 的形成。获得了具有 100ppm 浓度的直径范围为 12-18nm 的分散良好的 AgNPs。使用 SEM、EDX 和 TGA 对静电纺丝毡进行了表征。研究了其对不同种属的致病性/非致病性细菌金黄色葡萄球菌 ATCC 25923、铜绿假单胞菌 ATCC 27853 和大肠杆菌 ATCC 25922 以及真菌白色念珠菌 ATCC 10231 的抗菌活性。结果表明，与不含 AgNPs 的纳米纤维和单独的 AgNPs 相比，其具有优异的抗菌活性。
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