Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Carbohydr Polym. 2013 Feb 15;92(2):1033-9. doi: 10.1016/j.carbpol.2012.10.018. Epub 2012 Oct 13.
In this paper mixtures of two biocompatible polymers, dextran methacrylate (DEX-MA) with different molecular weights and scleroglucan (Scl), in its native form and as carboxymethyl derivative (Scl-CM), were tested as injectable and in situ cross-linkable systems. Rheological and texture analyses were carried out to better investigate the behavior of this kind of matrices. The combination of these polymers is able to assure adequate mechanical properties, suitable for biomedical applications. In addition swelling studies and in vitro release studies of three different biomolecules were also carried out.
本文研究了两种生物相容性聚合物——甲基丙烯酸葡聚糖（DEX-MA）和天然形式及羧甲基衍生物形式的葡聚糖（Scl-CM）的混合物，作为可注射和原位交联体系进行了测试。通过流变学和质地分析对这种基质的行为进行了更好的研究。这些聚合物的组合能够确保具有足够的机械性能，适用于生物医学应用。此外，还进行了三种不同生物分子的溶胀研究和体外释放研究。
