Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Carbohydr Polym. 2015 Aug 1;126:208-14. doi: 10.1016/j.carbpol.2015.03.016. Epub 2015 Mar 14.
A new derivative of dextran grafted with polyethylene glycol methacrylate through a carbonate bond (DEX-PEG-MA) has been synthesized and characterized. The photo-crosslinking reaction of DEX-PEG-MA allowed the obtainment of biodegradable networks tested for their mechanical and release properties. The new hydrogels were compared with those made of dextran methacrylate (DEX-MA), often employed as drug delivery systems of small molecules. The inclusion of PEG as a spacer created additional interactions among the polymeric chains improving the extreme fragility and lack of hardness typical of gels made of DEX-MA. Moreover, the different behavior in terms of swelling and degradability of the networks was able to affect the release of a model macromolecule over time, making DEX-PEG-MA matrices suitable candidates for the delivery of high molecular weight peptides. Interestingly, the combination of the two dextran derivatives showed intermediate ability to modulate the release of high molecular weight macromolecules.
通过碳酸酯键将聚乙二醇甲基丙烯酸酯接枝到葡聚糖上得到了一种新的衍生物（DEX-PEG-MA），并对其进行了合成和表征。DEX-PEG-MA 的光交联反应允许获得可生物降解的网络，对其机械性能和释放性能进行了测试。将新的水凝胶与葡聚糖甲基丙烯酸酯（DEX-MA）制成的水凝胶进行了比较，DEX-MA 常被用作小分子药物传递系统。PEG 作为间隔物的加入增加了聚合物链之间的相互作用，改善了由 DEX-MA 制成的凝胶的极脆和缺乏硬度的特性。此外，网络在溶胀和降解方面的不同行为能够影响模型大分子随时间的释放，使 DEX-PEG-MA 基质成为输送高分子量肽的合适候选物。有趣的是，两种葡聚糖衍生物的组合表现出了调节高分子量大分子释放的中间能力。
