Krebs J M, Schneider V S, Evans H, Kuo M C, LeBlanc A D
Krug International, NASA-Johnson Space Center, Houston, TX 77058.
Aviat Space Environ Med. 1990 Apr;61(4):314-8.
Inactivity causes profound changes. We determined the nature of the body composition changes due to inactivity, and sought to determine if these changes are secondary to changes in energy absorption. Volunteers were 15 healthy males who lived on a metabolic research ward under close staff supervision for 11 weeks. Subjects were ambulatory during the first 6 weeks and remained in continuous bed rest for the last 5 weeks of the study. Six male volunteers (age 24-61 years, height 175.7 +/- 4.2 cm) were selected for body composition measurements. Nine different male volunteers (age 21-50 years, height 177.7 +/- 5.0 cm) were selected for energy absorption measurements. The volunteers were fed weighed conventional foods on a constant 7-d rotation menu. The average daily caloric content was 2,592 kcal. Comparing the 5 weeks of continuous bed rest with the previous 6 weeks of ambulation we observed: no change in energy absorption or total body weight during bed rest, but a significant decrease in lean body mass and a significant increase in total body fat (p less than 0.05).
缺乏运动会导致深刻的变化。我们确定了因缺乏运动而引起的身体成分变化的性质，并试图确定这些变化是否继发于能量吸收的变化。志愿者为15名健康男性，他们在代谢研究病房中，在工作人员的密切监督下生活了11周。在研究的前6周，受试者可自由活动，在最后5周则持续卧床休息。挑选了6名男性志愿者（年龄24 - 61岁，身高175.7±4.2厘米）进行身体成分测量。挑选了9名不同的男性志愿者（年龄21 - 50岁，身高177.7±5.0厘米）进行能量吸收测量。志愿者按照固定的7天循环菜单食用经称重的常规食物。平均每日热量含量为2592千卡。将连续5周的卧床休息与之前6周的自由活动进行比较，我们观察到：卧床休息期间能量吸收和总体重没有变化，但去脂体重显著下降，全身脂肪显著增加（p<0.05）。
