Yang Yanzhou, Jin Yaping, Martyn Amanda C, Lin Pengfei, Song Yujie, Chen Fenglei, Hu Linyong, Cui Chenchen, Li Xiao, Li Qian, Lu Ray, Wang Aihua
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, PR China.
J Reprod Dev. 2013;59(3):245-51. doi: 10.1262/jrd.2012-137. Epub 2013 Feb 12.
Luman/CREB3 recruitment factor (LRF or CREBRF) was identified as a regulator of Luman (or CREB3) that is involved in the unfolded protein response during endoplasmic reticulum stress. Luman is implicated in a multitude of functions ranging from viral infection and immunity to cancer. The biological function of LRF, however, is unknown. In this paper, we report that uteri of pregnant mice and embryos displayed enhanced LRF expression at all stages, and the expressed LRF was found to be localized specifically at implantation sites. On the other hand, uteri of mice induced for delayed implantation or pseudopregnant mice showed low levels of LRF expression, suggesting that LRF mediates uterine receptivity during implantation. Further, expression of LRF was found to be modulated by steroid hormones such as progesterone and estradiol. This study thereby identifies a potential role for LRF in the process of implantation in uteri and development of preimplantation embryos in mice.
鲁曼/CREB3募集因子（LRF或CREBRF）被确定为鲁曼（或CREB3）的调节因子，它参与内质网应激期间的未折叠蛋白反应。鲁曼涉及从病毒感染、免疫到癌症等多种功能。然而，LRF的生物学功能尚不清楚。在本文中，我们报告怀孕小鼠的子宫和胚胎在所有阶段都表现出LRF表达增强，并且发现表达的LRF特异性定位于着床部位。另一方面，诱导延迟着床的小鼠子宫或假孕小鼠子宫显示出低水平的LRF表达，这表明LRF在着床期间介导子宫容受性。此外，发现LRF的表达受孕酮和雌二醇等类固醇激素的调节。因此，本研究确定了LRF在小鼠子宫着床过程和着床前胚胎发育中的潜在作用。
