Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China.
Chem Asian J. 2013 Apr;8(4):736-42. doi: 10.1002/asia.201201088. Epub 2013 Feb 10.
A reactive template method was used to fabricate alginate-based hydrogel microcapsules. The uniform and well-dispersed hydrogel capsules have a high drug loading capacity. After they are coated by a folate-linked lipid mixture on the surface, the capsules possess higher cell uptake efficiency by the molecule recognition between folate and the folate-receptor overexpressed by the cancer cells. Moreover, in this bioconjugate, the lipid could remarkably reduce the release rate of hydrophilic doxorubicin from the hydrogel microcapsules and encapsulate the hydrophobic photosensitizer hypocrellin B. The biointerfaced capsules could be used as drug carriers for combined treatment against cancer cell proliferation in vitro; this was much more effective than chemotherapy or photodynamic therapy alone.
采用反应性模板法制备了基于海藻酸盐的水凝胶微胶囊。所得水凝胶胶囊均匀分散，具有较高的载药能力。经叶酸连接的脂质混合物表面修饰后，由于叶酸与癌细胞过表达的叶酸受体之间的分子识别，胶囊具有更高的细胞摄取效率。此外，在该生物缀合物中，脂质可以显著降低水凝胶微胶囊中亲水性阿霉素的释放速率，并包封疏水性光增敏剂竹红菌素 B。生物界面胶囊可用作药物载体，用于体外联合治疗抑制癌细胞增殖，其效果明显优于单独的化疗或光动力疗法。
