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Role of flupirtine in the treatment of pain - chemistry and its effects.

作者信息

Singal Rikki, Gupta Parveen, Jain Nidhi, Gupta Samita

机构信息

Department of Surgery - Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, (Distt-Ambala), Haryana, India E.

出版信息

Maedica (Bucur). 2012 Jun;7(2):163-6.

PMID:23401726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3557425/
Abstract
摘要

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Role of flupirtine in the treatment of pain - chemistry and its effects.氟吡汀在疼痛治疗中的作用——化学性质及其效果
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Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer.氟吡汀与阿片类药物联合治疗：治疗癌症相关性神经病理性疼痛的开放标签病例系列
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Evaluating the role of flupirtine for postcraniotomy pain and compare it with diclofenac sodium: a prospective, randomized, double blind, placebo-controlled study.评价氟比洛芬酯用于开颅术后疼痛的作用，并与双氯芬酸钠进行比较：一项前瞻性、随机、双盲、安慰剂对照研究。
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Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states.氟吡汀。其药理特性及在疼痛状态下治疗效果的综述。
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[Treatment of tumor pain with flupirtine. Results of a double-blind study versus tramadol].[氟吡汀治疗肿瘤疼痛。与曲马多对比的双盲研究结果]
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Efficacy and tolerability of flupirtine in subacute/ chronic musculoskeletal pain - results of a patient level, pooled re-analysis of randomized, double-blind, controlled trials.氟吡汀治疗亚急性/慢性肌肉骨骼疼痛的疗效与耐受性——基于患者水平的随机双盲对照试验汇总再分析结果
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Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*.氟吡汀与曲马多治疗亚急性下腰痛患者的镇痛疗效及耐受性：一项双盲多中心试验*
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Am J Physiol Cell Physiol. 2021 Jun 1;320(6):C1074-C1087. doi: 10.1152/ajpcell.00536.2020. Epub 2021 Apr 14.
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Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?肺动脉高压中的离子通道：治疗学意义？
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Evaluation of Preoperative Flupirtine in Ambulatory Functional Endoscopic Sinus Surgery: A Prospective, Double-Blind, Randomized Controlled Trial.门诊功能性鼻内镜鼻窦手术中术前氟吡汀的评估：一项前瞻性、双盲、随机对照试验
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Role of flupirtine in reducing preoperative anxiety of patients undergoing craniotomy procedure.氟吡汀在减轻开颅手术患者术前焦虑中的作用。
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Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy.氟吡汀作为腹腔镜胆囊切除术患者超前镇痛药物的作用。
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Identification of Degradation Products and a Stability-Indicating RP-HPLC Method for the Determination of Flupirtine Maleate in Pharmaceutical Dosage Forms.降解产物的鉴定及一种用于测定药物剂型中马来酸氟吡汀的稳定性指示反相高效液相色谱法
Sci Pharm. 2013 Dec 9;82(2):281-93. doi: 10.3797/scipharm.1310-01. Print 2014 Apr-Jun.

本文引用的文献

1
Efficacy and tolerability of flupirtine in subacute/ chronic musculoskeletal pain - results of a patient level, pooled re-analysis of randomized, double-blind, controlled trials.氟吡汀治疗亚急性/慢性肌肉骨骼疼痛的疗效与耐受性——基于患者水平的随机双盲对照试验汇总再分析结果
Int J Clin Pharmacol Ther. 2011 Nov;49(11):637-47. doi: 10.5414/cp210000.
2
[Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension].[氟吡汀缓释剂对慢性背痛的镇痛及肌肉紧张度正常化作用。采用客观方法测量痛阈、耐痛阈及肌肉张力的标准化治疗评估结果]
MMW Fortschr Med. 2008 Jan 17;149 Suppl 4:153-61.
3
Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones.氟吡汀对海马神经元中一种G蛋白偶联内向整流钾电流的影响。
Br J Pharmacol. 1997 Dec;122(7):1333-8. doi: 10.1038/sj.bjp.0701519.
4
Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.手术后患者中马来酸氟吡汀与双氢可待因的比较。
Br J Anaesth. 1983 May;55(5):429-32. doi: 10.1093/bja/55.5.429.
5
[Pharmacokinetics and biotransformation of the analgesic flupirtine in humans].[镇痛药氟吡汀在人体中的药代动力学与生物转化]
Arzneimittelforschung. 1985;35(1):67-74.
6
[Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog].[大鼠和犬中镇痛药氟吡汀的药代动力学及生物转化]
Arzneimittelforschung. 1985;35(1):60-7.
7
Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery.马来酸氟吡汀口服制剂治疗骨科手术后疼痛的试验。
Curr Med Res Opin. 1985;9(9):594-601. doi: 10.1185/03007998509109640.
8
Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment.氟吡汀在老年志愿者和中度肾功能损害患者中的药代动力学。
Postgrad Med J. 1988 May;64(751):361-3. doi: 10.1136/pgmj.64.751.361.