手术后患者中马来酸氟吡汀与双氢可待因的比较。

Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.

作者信息

Moore R A, Bullingham R E, Simpson S, O'Sullivan G, Evans P J, McQuay H J, Lloyd J W

出版信息

Br J Anaesth. 1983 May;55(5):429-32. doi: 10.1093/bja/55.5.429.

DOI:10.1093/bja/55.5.429

Abstract

Flupirtine maleate 100 mg was compared with dihydrocodeine 60 mg when given by mouth to 50 women on the first 3 days following abdominal hysterectomy in a double-blind parallel-group trial. The analgesia produced was similar for both preparations, and the consumption of active drug was the same in both groups. The only significant differences in side-effects were an increased frequency of depression in patients receiving flupirtine and of sleepiness in those receiving dihydrocodeine.

摘要

在一项双盲平行组试验中，对50名接受腹部子宫切除术后头3天的女性口服给药，比较了100毫克马来酸氟吡汀与60毫克双氢可待因的效果。两种制剂产生的镇痛效果相似，两组的活性药物消耗量相同。副作用方面唯一显著的差异是，接受氟吡汀的患者抑郁发生率增加，接受双氢可待因的患者嗜睡发生率增加。