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妊娠期间结直肠癌 1 例:文献简要综述

A Case of Colorectal Cancer during Pregnancy: A Brief Review of the Literature.

作者信息

Khodaverdi Sepideh, Kord Valeshabad Ali, Khodaverdi Maryam

机构信息

Research Development Center, Shariati Hospital, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran.

出版信息

Case Rep Obstet Gynecol. 2013;2013:626393. doi: 10.1155/2013/626393. Epub 2013 Jan 14.

Abstract

The incidence of colorectal cancer (CRC) during pregnancy is so rare. Herein we present a case of colorectal cancer that was missed by pregnancy all over the pregnancy period. The patient was a 37-year-old woman (gravid 4, para 2) referred with the complaints of vaginal discharge and suspicious rupture of membrane (ROM). The patient was pale and the initial physical examination revealed dilation of two fingers, effacement about 30%. She underwent emergent cesarean section which showed adhesions surrounding the uterus, the bladder, and the abdominal wall. Forty days postoperatively, the patient presented with abdominal pain in the left upper quadrant (LUQ). Imaging confirmed a mass in LUQ. Partial colectomy of transverse colon (20 cm) was performed. Postoperative histopathologic study revealed a 7 ∗ 6 ∗ 5 cm mass in transverse colon compatible to stage IIa of the Duck class (T3, N0, Mx). Adjuvant chemotherapy was applied and the patient showed improvements during 7 months followup after surgery. Colorectal cancer in pregnancy is associated with diagnostic and therapeutic challenges which mostly lead to late diagnosis in advanced stages and poor prognosis. A targeted program to improve the general population knowledge and the establishment of a national consultant and screening program particularly for women with a planned pregnancy in the high risk group might be beneficial.

摘要

妊娠期结直肠癌(CRC)的发病率极为罕见。在此,我们报告一例在整个孕期均被漏诊的结直肠癌病例。患者为一名37岁女性(孕4产2),因阴道分泌物增多及可疑胎膜破裂(ROM)前来就诊。患者面色苍白,初次体格检查发现宫口开大两指,宫颈管消退约30%。她接受了急诊剖宫产,术中发现子宫、膀胱及腹壁周围有粘连。术后40天,患者出现左上腹(LUQ)疼痛。影像学检查证实左上腹有肿块。遂行横结肠部分切除术(20 cm)。术后组织病理学研究显示,横结肠有一个7×6×5 cm的肿块,符合杜克分期IIa期(T3,N0,Mx)。给予辅助化疗,术后7个月随访期间患者病情有所改善。妊娠期结直肠癌与诊断和治疗挑战相关,这大多导致晚期诊断及预后不良。开展一项提高普通人群认知的针对性项目,以及建立全国性咨询和筛查项目,尤其是针对高危组有计划妊娠的女性,可能会有所帮助。

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