Mousavi Seyed Mohsen, Somi Mohammad Hossein
Department of Molecular Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Asian Pac J Cancer Prev. 2009 Jul-Sep;10(3):407-12.
This literature review was carried out to provide an up-to-date perspective on gastric cancer clinicoepidemiological characteristics, to explain geographical differences, and to define public health priorities for prevention and early detection programs in Iran. A comprehensive search was conducted using different search engines and over 147 Persian medical journals from 1966 to December 2008. Inclusion criteria were published studies on gastric cancer clinical and epidemiological data. Abstracts only were excluded. Twenty five studies and two national cancer registry reports were also included. The average gastric cancer incidence rates were reported to be 15.2 (8.1 - 49.1) and 6.7(4.9-25.4) per 100,000 in males and females, respectively, with a ratio of 2.3:1 (1.5 - 2.7). More than two thirds of them were diagnosed in stage IV. Crude mortality rates were estimated at 15.5 and 8.4 per 100,000 in males and females. The trend for gastric cancer cases was increase from 1969 to 2004; antral adenocarcinomawas shifted to cardia adenocarcinoma in this period. The gastric cancer epidemiological aspects have changed during 4 decades; a Western pattern has been started in Iran where the incidence rate of adenocarcinoma of the most proximal cardia region and adjacent gastro-oesophageal junction has increased. Developing a gastric cancer early detection program, investigating gastric cancer risk factors, preventing patient and system delays, and providing national guidelines for treatment and palliation are all recommended.
开展这项文献综述是为了提供有关胃癌临床流行病学特征的最新观点，解释地域差异，并确定伊朗预防和早期检测项目的公共卫生重点。使用不同的搜索引擎以及1966年至2008年12月期间的147多种波斯语医学期刊进行了全面检索。纳入标准为已发表的关于胃癌临床和流行病学数据的研究。仅摘要被排除在外。还纳入了25项研究和两份国家癌症登记报告。据报告，男性和女性的胃癌平均发病率分别为每10万人15.2（8.1 - 49.1）和6.7（4.9 - 25.4），男女比例为2.3:1（1.5 - 2.7）。其中超过三分之二在IV期被诊断出来。男性和女性的粗死亡率估计分别为每10万人15.5和8.4。胃癌病例数的趋势从1969年到2004年呈上升趋势；在此期间，胃窦腺癌已转变为贲门腺癌。在40年期间，胃癌的流行病学情况发生了变化；伊朗已开始出现西方模式，即最靠近贲门区域和相邻胃食管交界处的腺癌发病率有所上升。建议开展胃癌早期检测项目，调查胃癌危险因素，防止患者和系统延误，并提供国家治疗和缓解指南。
