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颅神经麻痹:从结节病到系统性红斑狼疮。

Cranial nerve palsies: sarcoidosis to systemic lupus erythematosus.

作者信息

Aslam Fawad, Bannout Firas, Russell Elizabeth B

机构信息

Division of Rheumatology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA ; Division of Rheumatology, Department of Internal Medicine, John L. McClellan Memorial Veterans Hospital, Little Rock, AR 72205, USA.

出版信息

Case Rep Rheumatol. 2013;2013:175261. doi: 10.1155/2013/175261. Epub 2013 Jan 22.

DOI:10.1155/2013/175261
PMID:23401835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3564269/
Abstract

Cranial palsies are a very rare feature of SLE. Similarly, peripheral sensory-motor axonal neuropathy is very uncommon in SLE. The combination of the two as the presenting symptoms of SLE is a diagnostic challenge particularly in an elderly male patient with a known diagnosis of sarcoidosis. This case serves to highlight the diagnostic considerations in such a patient. The lack of response to standard therapy and the presence of subtle clues like anemia, proteinuria, and mild serositis should prompt the physician to look for alternate diagnoses. The potential association of SLE and sarcoidosis is also discussed. SLE can be present in elderly male patients with cranial and peripheral neuropathy.

摘要

颅神经麻痹是系统性红斑狼疮(SLE)非常罕见的特征。同样,周围感觉运动轴索性神经病在SLE中也非常少见。二者合并作为SLE的首发症状是一项诊断挑战,尤其对于一名已确诊结节病的老年男性患者。本病例旨在强调对此类患者的诊断考量。对标准治疗无反应以及存在如贫血、蛋白尿和轻度浆膜炎等细微线索,应促使医生寻找其他诊断。还讨论了SLE与结节病的潜在关联。SLE可出现在患有颅神经和周围神经病变的老年男性患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/3564269/1a5eccefcb38/CRIM.RHEUMATOLOGY2013-175261.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/3564269/1a5eccefcb38/CRIM.RHEUMATOLOGY2013-175261.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/3564269/1a5eccefcb38/CRIM.RHEUMATOLOGY2013-175261.001.jpg

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本文引用的文献

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Semin Arthritis Rheum. 2011 Oct;41(2):203-11. doi: 10.1016/j.semarthrit.2011.04.001.
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EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs.EULAR 推荐的伴有神经精神表现的系统性红斑狼疮的管理:EULAR 常务委员会临床事务工作组的报告。
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Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations.
神经精神性狼疮表现的发病机制、诊断和治疗。
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Neuropsychiatric manifestations of systemic lupus erythematosus.系统性红斑狼疮的神经精神表现
Joint Bone Spine. 2006 Dec;73(6):639-45. doi: 10.1016/j.jbspin.2006.05.006. Epub 2006 Sep 20.
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Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors.系统性红斑狼疮中的神经精神障碍与抗N-甲基-D-天冬氨酸受体抗体有关。
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Endothelium and the brain in CNS lupus.中枢神经系统狼疮中的内皮与脑
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