Wojtusik Sylwia, Sułowicz Władysław
Katedra i Klinika Nefrologii, Uniwersytet Jagielloński, Collegium Medicum w Krakowie.
Przegl Lek. 2012;69(9):680-6.
Blood pressure control is regulated by complicated physiological mechanisms, which are dependent upon cardio-vascular, neurological, endocrine systems and the kidneys. The kidneys plays an important role in the regulation of blood pressure based on sodium and water balance, renin-an. giotensin-aldosterone axis, sympathetic activity as well as other regulatory substances like: natriuretic peptides (ANP, BNP) endothelin, dopamine, prostaglandins and nitric oxide (NO). In chronic kidney disease (CKD) patients hypertension is extremely common and is aggravated together with the lowering of renal clearance (GFR). The kidneys may be a cause and a culprit of hypertension.
血压控制由复杂的生理机制调节，这些机制依赖于心血管、神经、内分泌系统以及肾脏。肾脏在基于钠和水平衡、肾素 - 血管紧张素 - 醛固酮轴、交感神经活动以及其他调节物质（如利钠肽（心房钠尿肽、脑钠肽）、内皮素、多巴胺、前列腺素和一氧化氮）来调节血压方面发挥着重要作用。在慢性肾脏病（CKD）患者中，高血压极为常见，并且随着肾清除率（肾小球滤过率）的降低而加重。肾脏可能是高血压的起因和罪魁祸首。
