烟酰胺腺嘌呤二核苷酸脱氢酶亚基2 237 Leu/Met多态性与饮用绿茶对日本男性健康体检者肾功能的意外联合作用：一项横断面研究。

Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.

作者信息

Kokaze Akatsuki, Ishikawa Mamoru, Matsunaga Naomi, Karita Kanae, Yoshida Masao, Ohtsu Tadahiro, Ochiai Hirotaka, Shirasawa Takako, Nanri Hinako, Hoshino Hiromi, Takashima Yutaka

机构信息

Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

出版信息

J Negat Results Biomed. 2013 Nov 20;12:17. doi: 10.1186/1477-5751-12-17.

DOI:10.1186/1477-5751-12-17

PMID:24252463

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3842666/

Abstract

BACKGROUND

NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in Japanese. A previous study has shown that ND2-237 Leu/Met polymorphism modulates the effects of green tea consumption on risk of hypertension. For men with ND2-237Leu, habitual green tea consumption may reduce the risk of hypertension. Moreover, there is a combined effect of ND2-237 Leu/Met polymorphism and alcohol consumption on risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m2). Several beneficial effects of green tea on the kidney have been reported. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of green tea consumption on risk of mildly decreased eGFR in male Japanese health check-up examinees.

RESULTS

For ND2-237Leu genotypic men, after adjustment for confounding factors, green tea consumption may increase the risk of mildly decreased eGFR (P for trend = 0.016). The adjusted odds ratio (OR) for mildly decreased eGFR was significantly higher in subjects with ND2-237Leu who consume ≥6 cups of green tea per day than those who consume ≤1 cup of green tea per day (adjusted OR = 5.647, 95% confidence interval: 1.528-20.88, P = 0.009). On the other hand, for ND2-237Met genotypic men, green tea consumption does not appear to determine the risk of mildly decreased eGFR.

CONCLUSION

The present results suggest that ND2-237 Leu/Met polymorphism unexpectedly modifies the effects of green tea consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.

摘要

背景

烟酰胺腺嘌呤二核苷酸（NADH）脱氢酶亚基2第237位亮氨酸/甲硫氨酸（ND2 - 237 Leu/Met）多态性与日本人的长寿有关。先前的一项研究表明，ND2 - 237 Leu/Met多态性可调节饮用绿茶对高血压风险的影响。对于携带ND2 - 237Leu的男性，经常饮用绿茶可能会降低高血压风险。此外，ND2 - 237 Leu/Met多态性与饮酒对估计肾小球滤过率（eGFR）轻度降低（<90 ml/min/1.73 m²）的风险存在联合作用。已有多项关于绿茶对肾脏有益作用的报道。本研究的目的是调查ND2 - 237 Leu/Met多态性是否会改变饮用绿茶对日本男性健康体检者eGFR轻度降低风险的影响。

结果

对于携带ND2 - 237Leu基因型的男性，在调整混杂因素后，饮用绿茶可能会增加eGFR轻度降低的风险（趋势P值 = 0.016）。每天饮用≥6杯绿茶的ND2 - 237Leu基因型受试者，其eGFR轻度降低的校正比值比（OR）显著高于每天饮用≤1杯绿茶的受试者（校正OR = 5.647，95%置信区间：1.528 - 20.88，P = 0.009）。另一方面，对于携带ND2 - 237Met基因型的男性，饮用绿茶似乎不会影响eGFR轻度降低的风险。