Instituto de Ciencia de Materiales de Sevilla (CSIC-US), Isla de La Cartuja, 41092 Sevilla, Spain.
Langmuir. 2013 Mar 12;29(10):3411-8. doi: 10.1021/la4001076. Epub 2013 Mar 1.
A procedure for the synthesis of multifunctional europium(III)-doped gadolinium(III) fluoride (Eu:GdF3) nanoparticles (~85 nm) with quasispherical shape by precipitation at 120 °C from diethylene glycol solutions containing lanthanide chlorides and an ionic liquid (1-Butyl, 2-methylimidazolium tetrafluoroborate) as fluoride source has been developed. These nanoparticles were polycrystalline and crystallized into a hexagonal structure, which is unusual for GdF3. They were also mesoporous (pore size = 3.5 Å), having a rather high BET surface area (75 m(2) g(-1)). The luminescent and magnetic (relaxivity) properties of the Eu:GdF3 nanoparticles have been also evaluated in order to assess their potentiality as "in vitro" optical biolabels and contrast agent for magnetic resonance imaging. Finally, a procedure for their functionalization with aspartic-dextran polymers is also reported. The functionalized Eu:GdF3 nanoparticles presented negligible toxicity for Vero cells, which make them suitable for biotecnological applications.
一种通过在 120°C 下从含有镧系氯化物和离子液体（1-丁基-2-甲基咪唑四氟硼酸盐）的二乙二醇溶液中沉淀合成具有准球形形状的多功能铕（III）掺杂镓（III）氟化物（Eu：GdF3）纳米粒子（~85nm）的方法已经被开发出来。这些纳米粒子为多晶，结晶成六方结构，这对于 GdF3 来说是不寻常的。它们也是介孔的（孔径=3.5Å），具有相当高的 BET 表面积（75m2g-1）。还评估了 Eu：GdF3 纳米粒子的发光和磁性（弛豫率）性质，以评估它们作为“体外”光学生物标记物和磁共振成像对比剂的潜力。最后，还报告了用天冬氨酸-葡聚糖聚合物对其进行功能化的方法。功能化的 Eu：GdF3 纳米粒子对 Vero 细胞的毒性可忽略不计，这使得它们适用于生物技术应用。
