雌激素暴露与女性帕金森病风险：丹麦一项前瞻性队列研究。
Exposure to estrogen and women's risk for Parkinson's disease: a prospective cohort study in Denmark.
机构信息
Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
出版信息
Parkinsonism Relat Disord. 2013 Apr;19(4):457-60. doi: 10.1016/j.parkreldis.2013.01.008. Epub 2013 Feb 9.
BACKGROUND
Studies have suggested that estrogen is protective against Parkinson's disease; however, the results have been inconsistent.
METHODS
Our cohort comprised 27,466 women from the prospective Diet, Cancer and Health study. At inclusion, all the cohort members filled in questionnaires on diet and lifestyle, including reproductive factors, use of hormone products, and smoking habits. The cohort was followed up for Parkinson's disease in the Danish Hospital Register, and risks associated with indicators of exposure to estrogen were estimated in a Cox proportional hazards model.
RESULTS
No significant association was found between reproductive factors and risk for Parkinson's disease. Use of oral contraceptives was associated with a nonsignificantly increased risk (hazard ratio, 1.30; 95% confidence interval, 0.81-2.09), as was use of hormone replacement therapy (1.41; 0.90-2.21).
CONCLUSIONS
Our data do not support the hypothesis of a protective effect of estrogen on the risk for Parkinson's disease in women.
背景
研究表明雌激素对帕金森病具有保护作用，但结果并不一致。
方法
我们的队列包括来自前瞻性饮食、癌症与健康研究的 27466 名女性。在纳入时，所有队列成员都填写了关于饮食和生活方式的问卷，包括生育因素、激素产品的使用和吸烟习惯。该队列在丹麦医院登记处随访帕金森病的发生情况，并在 Cox 比例风险模型中估计了暴露于雌激素指标的相关风险。
结果
生育因素与帕金森病风险之间无显著关联。口服避孕药的使用与风险增加无显著相关性（风险比，1.30；95%置信区间，0.81-2.09），激素替代疗法也是如此（1.41；0.90-2.21）。
结论
我们的数据不支持雌激素对女性帕金森病风险具有保护作用的假说。
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