Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Mov Disord. 2012 Sep 1;27(10):1283-9. doi: 10.1002/mds.25125. Epub 2012 Jul 25.
It has been hypothesized that welders are at increased risk for neurological disorders, including Parkinson's disease, but few well-designed cohort studies have been conducted. The risk for Parkinson's disease and other neurodegenerative disorders was examined in an updated follow-up study based on a previous cohort of 5867 Danish welders and 1735 nonwelding metal workers exposed to welding fume. Occupational history and information on smoking were obtained from questionnaires, supplemented by information from the compulsory Danish Supplementary Pension Fund. Hospital contacts, including outpatient data from 1994, for Parkinson's disease and other neurological disorders were ascertained from the Danish National Hospital Register. Based on first-time hospital contacts, standardized hospitalization ratios (SHRs) were calculated for the entire cohort and for welders, metal workers, and nonresponders separately and for the general Danish population in 1987-2008. In an internal analysis of welders, Cox proportional hazard models were used to estimate hospitalization rate ratios (HRRs) for Parkinson's disease associated with lifelong exposure to welding. Overall, 45 cohort members had a hospital contact for Parkinson's disease (SHR, 1.12; 95% confidence interval [CI], 0.82-1.50), of whom 25 were welders (standardized incidence rate ratio, 1.05; 95% CI, 0.68-1.55). When duration of welding was compared among 5736 welders, the HRR was 0.83 (95% CI, 0.59-1.16) per 10 years' welding, after adjustment for smoking. The results of this study do not support the hypothesis that welders are at increased risk for Parkinson's disease; these findings are consistent with those of our previously published analysis. © 2012 Movement Disorder Society.
人们推测焊工患神经紊乱疾病（包括帕金森病）的风险较高，但很少有精心设计的队列研究对此进行了探讨。在一项基于之前对 5867 名丹麦焊工和 1735 名接触过焊接烟尘的非焊接金属工人的队列研究的更新随访研究中，检查了帕金森病和其他神经退行性疾病的风险。通过问卷调查获取职业史和吸烟信息，并通过丹麦强制性补充养老金基金的信息加以补充。通过丹麦国家医院登记处，获取帕金森病和其他神经紊乱疾病的住院记录，包括 1994 年以来的门诊数据。根据首次住院记录，计算了整个队列以及焊工、金属工人和未应答者的标准化住院比值（SHR），并计算了 1987-2008 年丹麦普通人群的 SHR。在焊工的内部分析中，使用 Cox 比例风险模型来估计与终生接触焊接相关的帕金森病的住院率比值（HRR）。总体而言，45 名队列成员有帕金森病的住院记录（SHR，1.12；95%置信区间 [CI]，0.82-1.50），其中 25 名是焊工（标准化发病比，1.05；95%CI，0.68-1.55）。在对 5736 名焊工的焊接时间进行比较时，调整吸烟因素后，HRR 为每 10 年焊接 0.83（95%CI，0.59-1.16）。这项研究的结果不支持焊工患帕金森病风险增加的假说；这些发现与我们之前发表的分析结果一致。© 2012 运动障碍学会。
