Carbone Peter N, Carbone David L, Carstairs Shaun D, Luzi Scott A
Department of Anatomic Pathology, Naval Medical Center San Diego, San Diego, CA 92134, USA.
Am J Forensic Med Pathol. 2013 Mar;34(1):26-8. doi: 10.1097/PAF.0b013e31827ab5da.
The rise in popularity of "bath salts" as safe alternatives to MDMA (3,4-methylenedioxymethamphetamine), methamphetamine, and other illicit substances has resulted in increased scrutiny of the contents and toxicology associated with these products. We report a case of sudden death related to the synthetic cathinone methylone (3,4-methylenedioxy-N-methylcathinonmethylone) in a previously healthy 19-year-old man. Although several fatal case reports have been published involving methylone and other synthetic cathinones, this is the first reported case of sudden cardiac death associated with methylone use. Although lack of published data prevented a comparison of blood methylone concentrations between our case and existing reports, the amount of methylone we detected postmortem (0.07 mg/dL) is below those reported in MDMA-related fatalities. Our report suggests that methylone toxicity has been greatly underestimated by users of this synthetic cathinone.
“浴盐”作为摇头丸（3,4-亚甲基二氧甲基苯丙胺）、甲基苯丙胺及其他非法物质的安全替代品，其人气上升导致对这些产品的成分及毒理学的审查日益严格。我们报告了一例与合成卡西酮甲酮（3,4-亚甲基二氧-N-甲基卡西酮甲酮）相关的猝死病例，死者是一名此前健康的19岁男性。尽管已有数篇涉及甲酮及其他合成卡西酮的致命病例报告发表，但这是首例与使用甲酮相关的心脏性猝死报告。虽然缺乏已发表的数据，无法将我们病例中的血液甲酮浓度与现有报告进行比较，但我们在尸检时检测到的甲酮量（0.07毫克/分升）低于与摇头丸相关死亡病例报告中的含量。我们的报告表明，这种合成卡西酮的使用者大大低估了甲酮的毒性。
