Pfizer Inc., New York, NY, USA.
Menopause. 2013 May;20(5):518-24. doi: 10.1097/GME.0b013e31827d38a5.
The current study characterizes health-related quality of life, work productivity, and resource use among postmenopausal women by severity of vasomotor symptoms (VMS).
Participants were selected from the 2010 US National Health and Wellness Survey. Women aged 40 to 75 years who did not report a history of menstrual bleeding or spotting for 1 year were eligible for analysis (N = 3,267). Cohorts of women with no VMS (n = 1,740), mild VMS (n = 931), moderate VMS (n = 462), and severe VMS (n = 134) were compared after controlling for demographic and health characteristics. Outcome measures were assessed using linear models and included health status, work productivity within the past 7 days, and healthcare resource use within the past 6 months.
The mean age of women experiencing severe VMS was 57.92 years. After demographic and health characteristics had been controlled for, women experiencing severe and moderate VMS reported significantly lower mean health status scores compared with women with no symptoms (P < 0.0001). The mean number of menopause symptom-related physician visits was significantly greater among women with severe, moderate, or mild symptoms than among women with no symptoms (P < 0.0001). Among employed women experiencing VMS, women with severe and moderate symptoms had adjusted presenteeism of 24.28% and 14.3%, versus 4.33% in women with mild symptoms (P < 0.001), and activities of daily living impairment of 31.66% and 17.06%, versus 6.16% in women with mild symptoms (P < 0.0001).
In postmenopausal women, a greater severity of VMS is significantly associated with lower levels of health status and work productivity, and greater healthcare resource use.
本研究通过血管舒缩症状（VMS）严重程度对绝经后女性的健康相关生活质量、工作生产力和资源利用进行了描述。
参与者选自 2010 年美国国家健康与健康调查。年龄在 40 至 75 岁之间、且报告过去 1 年无月经出血或点滴出血史的女性有资格进行分析（N=3267）。无 VMS（n=1740）、轻度 VMS（n=931）、中度 VMS（n=462）和重度 VMS（n=134）的女性队列在控制人口统计学和健康特征后进行了比较。使用线性模型评估了健康状况、过去 7 天内的工作生产力和过去 6 个月内的医疗资源使用情况。
经历严重 VMS 的女性的平均年龄为 57.92 岁。在控制了人口统计学和健康特征后，与无症状女性相比，经历严重和中度 VMS 的女性报告的健康状况评分明显较低（P<0.0001）。有严重、中度或轻度症状的女性与无症状女性相比，与绝经症状相关的医生就诊次数明显较多（P<0.0001）。在经历 VMS 的有工作女性中，与轻度症状的女性相比，严重和中度症状的女性调整后的工作出席率分别为 24.28%和 14.3%（P<0.001），日常生活活动受损率分别为 31.66%和 17.06%（P<0.0001）。
在绝经后女性中，VMS 严重程度越高与健康状况和工作生产力降低以及医疗资源利用增加显著相关。
