Williams R E, Kalilani L, DiBenedetti D Britt, Zhou X, Granger A L, Fehnel S E, Levine K B, Jordan J, Clark R V
Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA.
Climacteric. 2008 Feb;11(1):32-43. doi: 10.1080/13697130701744696.
To describe characteristics of vasomotor symptoms, specifically daily frequency and severity, among women 40-65 years old in the United States (US).
A survey was completed by a nationally representative sample of 4402 US women aged 40-65 years old. A questionnaire focusing on menopausal symptoms was administered online in April 2005.
The prevalence of vasomotor symptoms was 79% in peri- and 65% in postmenopausal women. Women with daily vasomotor symptoms had an average of 2.5 very mild/mild, 2.6 moderate, 2.5 severe, and 1.4 very severe daytime hot flushes in a typical day. Women with night sweats every night had an average of 2.4 moderate, 3.2 severe, and 2.7 very severe night sweats in a typical night. Overall, 9% of peri- and 7% of postmenopausal women reported 7+ moderate to very severe vasomotor symptoms in a typical day. Although some women reported that symptoms were worse in the evening and in the summer, many women reported they were consistent, both throughout the day and throughout the seasons of the year.
The Menopause Epidemiology Study builds upon existing literature by providing data on daily frequency and severity of vasomotor symptoms. There are many women with frequent and severe vasomotor symptoms who may benefit from treatment.
描述美国40 - 65岁女性血管舒缩症状的特征，特别是每日发作频率和严重程度。
对4402名年龄在40 - 65岁的美国女性进行了一项全国代表性抽样调查。2005年4月通过在线方式发放了一份聚焦更年期症状的问卷。
血管舒缩症状的患病率在围绝经期女性中为79%，在绝经后女性中为65%。有每日血管舒缩症状的女性在典型的一天中，平均有2.5次非常轻微/轻微、2.6次中度、2.5次重度和1.4次非常重度的日间潮热。每晚有盗汗的女性在典型的一晚中，平均有2.4次中度、3.2次重度和2.7次非常重度的盗汗。总体而言，9%的围绝经期女性和7%的绝经后女性报告在典型的一天中有7次及以上中度至非常重度的血管舒缩症状。尽管一些女性报告症状在晚上和夏季更严重，但许多女性表示症状在一整天和一年的各个季节中都是持续的。
更年期流行病学研究通过提供血管舒缩症状的每日发作频率和严重程度的数据，对现有文献进行了补充。有许多血管舒缩症状频繁且严重的女性可能会从治疗中受益。
