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α硫辛酸与水飞蓟素对膀胱出口梗阻的影响。

Effect of αlipoic acid and silymarin on bladder outlet obstruction.

作者信息

Yildirim Abidin, Başeskioğlu Barbaros, Temel Halide E, Erkasap Nilüfer, Yenilmez Aydin, Uslu Sema, Ozer Caner, Ozkurt Mete, Dönmez Turgut

机构信息

Department of Urology, Faculty of Medicine, Osmangazi University; Eskişehir, Turkey.

出版信息

Exp Ther Med. 2013 Feb;5(2):596-602. doi: 10.3892/etm.2012.831. Epub 2012 Nov 23.

DOI:10.3892/etm.2012.831
PMID:23403734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3570162/
Abstract

The aim of the present study was to determine whether the treatment of obstructed rat bladders with αlipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction (BOO). A total of 32 adult Sprague Dawley rats were divided into four groups (n=8 per group): sham (placebo surgery) animals with no treatment (group 1); control animals with surgically induced BOO (group 2); obstructed rats treated with ALA (group 3); and obstructed rats treated with silymarin (group 4). Histological evaluation, bladder weights, collagen structure, TdT-mediated biotin nick end-labeling (TUNEL), inducible nitric oxide sentase (iNOS) mRNA levels, malondialdehyde (MDA) levels and tumor necrosis factor (TNF) levels were investigated. The ALA-treated group had similar bladder weights, collagen levels and TUNEL positivity and decreased iNOS levels compared with the control group, while the silymarin group exhibited further differences. Serum MDA and TNF-α levels were both decreased in the ALA and silymarin groups. ALA treatment reduced the increased oxidative stress and bladder inflammation caused by BOO and may contribute to the protection of bladder function.

摘要

本研究的目的是确定用α硫辛酸（ALA）和水飞蓟宾治疗梗阻性大鼠膀胱是否能逆转对膀胱出口梗阻（BOO）的生化和生理反应。总共32只成年Sprague Dawley大鼠被分为四组（每组n = 8）：未治疗的假手术（安慰剂手术）动物（第1组）；手术诱导BOO的对照动物（第2组）；用ALA治疗的梗阻大鼠（第3组）；以及用水飞蓟宾治疗的梗阻大鼠（第4组）。研究了组织学评估、膀胱重量、胶原蛋白结构、TdT介导的生物素缺口末端标记（TUNEL）、诱导型一氧化氮合酶（iNOS）mRNA水平、丙二醛（MDA）水平和肿瘤坏死因子（TNF）水平。与对照组相比，ALA治疗组的膀胱重量、胶原蛋白水平和TUNEL阳性率相似，iNOS水平降低，而水飞蓟宾组表现出进一步的差异。ALA和水飞蓟宾组的血清MDA和TNF-α水平均降低。ALA治疗减轻了BOO引起的氧化应激增加和膀胱炎症，可能有助于保护膀胱功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/a7ce9b59c701/ETM-05-02-0596-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/d67052dcbbf5/ETM-05-02-0596-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/585f4db155b7/ETM-05-02-0596-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/9185b5f59863/ETM-05-02-0596-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/a7ce9b59c701/ETM-05-02-0596-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/d67052dcbbf5/ETM-05-02-0596-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/585f4db155b7/ETM-05-02-0596-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/9185b5f59863/ETM-05-02-0596-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7d/3570162/a7ce9b59c701/ETM-05-02-0596-g03.jpg

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