通过自由基合成获得有机金属芳基钴啉：4-乙基苯并钴胺素，一种潜在的“抗维生素 B(12)”。

Access to organometallic arylcobaltcorrins through radical synthesis: 4-ethylphenylcobalamin, a potential "antivitamin B(12)".

机构信息

Institute of Organic Chemistry and Centre of Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

出版信息

Angew Chem Int Ed Engl. 2013 Feb 25;52(9):2606-10. doi: 10.1002/anie.201209651. Epub 2013 Feb 13.

DOI:10.1002/anie.201209651

PMID:23404623

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3843227/

Abstract

Locked B(12): 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B(12) antimetabolite features a strong Co-C bond, and represents a "locked" form of vitamin B(12) . It may be used in animal studies to induce functional vitamin B(12) deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B(12) deficiency.

摘要

锁定 B(12)：4-乙基苯并钴胺素，一种新型的有机金属芳基钴胺素，已通过自由基反应合成。这种维生素 B(12) 抗代谢物具有很强的 Co-C 键，代表了维生素 B(12) 的“锁定”形式。它可能用于动物研究中，人为诱导功能性维生素 B(12) 缺乏，以帮助阐明与维生素 B(12) 缺乏的病理生理学相关的仍有争议的问题。