Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Chemistry. 2020 Dec 1;26(67):15438-15445. doi: 10.1002/chem.202003788. Epub 2020 Nov 3.
The recently delineated structure- and reactivity-based concept of antivitamins B has begun to bear fruit by the generation, and study, of a range of such B -dummies, either vitamin B -derived, or transition metal analogues that also represent potential antivitamins B or specific B -antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B -chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B -deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B to induce functional B -deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells.
最近提出的基于结构和反应性的抗维生素 B 概念已经开始取得成果，通过生成和研究一系列这样的 B 类假分子，包括维生素 B 衍生的或过渡金属类似物，它们也代表潜在的抗维生素 B 或特定的 B 类抗代谢物。正如这里所综述的，这为有机金属 B 化学和生物无机配位化学开辟了新的研究途径。此外，对抗维生素 B 的探索性研究揭示了它们作为具有药理学意义的化合物的一些潜力，可在一系列生物体中诱导 B 缺乏，从医院耐药菌到实验小鼠。抗维生素 B 诱导哺乳动物细胞和器官功能性 B 缺乏的能力也表明它们作为人类和动物癌细胞生长抑制剂的潜在价值。
