Department of Nutrition, Institute of Basic Medical Science, Faculty of Medicine, University of Oslo, Oslo, Norway.
Obesity (Silver Spring). 2013 Mar;21(3):E294-302. doi: 10.1002/oby.20011.
Stearoyl-coenzyme A desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism. Increased hepatic SCD1 activity is associated with obesity and obesity-related diseases. We examined the relations of two plasma SCD activity indices (16:1n-7/16:0, 18:1n-9/18:0) with body composition, and the association of lifestyle and dietary variables with the plasma SCD indices.
This population-based, cross-sectional study of 2021 elderly (71-74 y) men and women from the Hordaland Health Study in Western Norway was conducted using a validated food frequency questionnaire, body composition measurements by dual-energy X-ray absorptiometry and determination of the plasma fatty acid profile.
In multivariate regression analyses, plasma SCD indices were positively associated with BMI and body fat (P < 0.001 for both). From the 2.5th to 97.5th percentiles of plasma SCD-16 and SCD-18 indices, fat mass differed by about 8 kg and 5 kg, respectively. Intake of polyunsaturated fatty acids were negatively associated with SCD-16 (partial r = -0.30) and SCD-18 (partial r = -0.24) (P < 0.001 for both). Alcohol intake was positively associated with SCD-16 (partial r = 0.26) and SCD-18 (partial r = 0.16) (P < 0.001 for both), whereas coffee consumption and physical activity were inversely associated with SCD-16 (P = 0.026 and P = 0.006, respectively) and SCD-18 (P = 0.001 and P = 0.022, respectively).
In this elderly population, plasma markers of SCD1 activity are associated with increased adiposity. Furthermore, modifiable dietary habits and lifestyle are associated with plasma SCD indices. These results suggest that SCD1 activity may be a promising target for weight control.
硬脂酰辅酶 A 去饱和酶-1（SCD1）是脂肪酸和能量代谢的关键酶。肝 SCD1 活性的增加与肥胖和肥胖相关疾病有关。我们研究了两种血浆 SCD 活性指数（16:1n-7/16:0、18:1n-9/18:0）与身体成分的关系，以及生活方式和饮食变量与血浆 SCD 指数的关系。
这是一项基于人群的横断面研究，对来自挪威西部 Hordaland 健康研究的 2021 名老年（71-74 岁）男性和女性进行了研究，使用了经过验证的食物频率问卷、双能 X 射线吸收法测定的身体成分测量值和血浆脂肪酸谱的测定。
在多元回归分析中，血浆 SCD 指数与 BMI 和体脂肪呈正相关（两者均 P<0.001）。从血浆 SCD-16 和 SCD-18 指数的第 2.5 至 97.5 百分位数来看，脂肪量分别相差约 8 公斤和 5 公斤。多不饱和脂肪酸的摄入量与 SCD-16（偏相关系数 r = -0.30）和 SCD-18（偏相关系数 r = -0.24）呈负相关（两者均 P<0.001）。酒精摄入量与 SCD-16（偏相关系数 r = 0.26）和 SCD-18（偏相关系数 r = 0.16）呈正相关（两者均 P<0.001），而咖啡消费和体力活动与 SCD-16（P=0.026 和 P=0.006）和 SCD-18（P=0.001 和 P=0.022）呈负相关。
在这个老年人群中，SCD1 活性的血浆标志物与肥胖增加有关。此外，可改变的饮食习惯和生活方式与血浆 SCD 指数有关。这些结果表明，SCD1 活性可能是控制体重的一个有希望的靶点。
