Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain.
Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain.
Nutrients. 2020 Jun 25;12(6):1895. doi: 10.3390/nu12061895.
This study investigates the still uncertain association between serum phospholipid fatty acids (PL-FA), and anthropometric and adiposity variables. A cross-sectional study was conducted with 1443 Spanish premenopausal women. Participants answered an epidemiological and a food frequency questionnaire. Anthropometric variables were measured using a bioimpedance scale. Serum PL-FAs levels were determined by gas chromatography-mass spectrometry. The association between body mass index (BMI), weight gain, body fat percentage, visceral fat index, and waist circumference with serum PL-FAs and desaturation indices was evaluated using multivariable linear regression models. BMI was positively associated with the relative concentration of saturated fatty acids (SFAs) (β = 0.94, q-val = 0.001), and with palmitoleic, dihomo-γ-linolenic (DGLA), arachidonic (AA) and α-linolenic acids, and was inversely associated with oleic, gondoic, trans-vaccenic, linoleic and γ-linolenic acids. Total fat percentage was positively associated with DGLA and AA, and inversely with linoleic and γ-linolenic acids. Low relative concentrations of some SFAs and high levels of n-6 PUFAs were associated with greater waist circumference. While the oleic/stearic and AA/DGLA acid ratios were inversely associated with BMI, DGLA/linoleic acid ratio was positively related to almost all variables. In addition to BMI, total fat percentage and waist circumference were also associated with certain individual fatty acids.
本研究旨在探讨血清磷脂脂肪酸（PL-FA）与人体测量学和肥胖变量之间仍不确定的关联。这是一项横断面研究，共纳入了 1443 名西班牙绝经前女性。参与者回答了一份流行病学问卷和一份食物频率问卷。采用生物电阻抗秤测量人体测量学变量。通过气相色谱-质谱法测定血清 PL-FA 水平。使用多变量线性回归模型评估体重指数（BMI）、体重增加、体脂肪百分比、内脏脂肪指数和腰围与血清 PL-FA 和脱饱和指数之间的关系。BMI 与饱和脂肪酸（SFA）的相对浓度呈正相关（β=0.94，q 值=0.001），与棕榈油酸、二高-γ-亚麻酸（DGLA）、花生四烯酸（AA）和α-亚麻酸呈正相关，与油酸、二十碳五烯酸、反式- vaccenic、亚油酸和γ-亚麻酸呈负相关。总脂肪百分比与 DGLA 和 AA 呈正相关，与亚油酸和γ-亚麻酸呈负相关。某些 SFA 的相对浓度较低和 n-6PUFA 水平较高与腰围较大有关。虽然油酸/硬脂酸和 AA/DGLA 酸比值与 BMI 呈负相关，但 DGLA/亚油酸比值与几乎所有变量均呈正相关。除 BMI 外，总脂肪百分比和腰围也与某些特定脂肪酸有关。
