采用光敏剂功能化的金纳米星的单连续波激光诱导光动力/等离子体光热治疗。
Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.
机构信息
Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu 210000, China.
出版信息
Adv Mater. 2013 Jun 11;25(22):3055-61. doi: 10.1002/adma.201204623. Epub 2013 Feb 13.
Abstract
Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.
摘要
氯 e6 修饰的金纳米星（GNS-PEG-Ce6）在单激光照射下用于进行光动力/等离子体光热治疗（PDT/PPTT）的同步治疗。早期 PDT 效应与晚期 PPTT 效应协同作用，获得协同抗癌效率。所制备的 GNS-PEG-Ce6 表现出优异的水分散性、良好的生物相容性、增强的细胞摄取和显著的体内照射抗癌效率。
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